Emerging Biopharmaceuticals from Marine Actinobacteria

Abstract Actinobacteria are quotidian microorganisms in the marine world, playing a crucial ecological role in the recycling of refractory biomaterials and producing novel secondary metabolites with pharmaceutical applications. Actinobacteria have been isolated from the huge area of marine organisms...

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Bibliographic Details
Published in:Environmental toxicology and pharmacology 2017-01, Vol.49, p.34-47
Main Authors: ul Hassan, Syed Shams, Anjum, Komal, Abbas, Syed Qamar, Akhter, Najeeb, Shagufta, Bibi Ibtesam, Shah, Sayed Asmat Ali, Tasneem, Umber
Format: Article
Language:English
Subjects:
Actinobacteria
Actinobacteria - metabolism
Algae
Alkaloids
Animals
Biological Products - metabolism
Biomaterials
Biomedical materials
Biopharmaceuticals
Cancer
Chemistry
Corals
Crabs
Crustaceans
Drugs
Emergency
HIV
Human immunodeficiency virus
Humans
Inflammatory
Knowledge
Mangroves
Marine actinobacteria
Marine microorganisms
Marine organisms
Marine resources
Metabolites
Microorganisms
Mollusks
Natural products
Peptides
Polyketides
Recycling
Seawater - microbiology
Seaweeds
Secondary metabolites
Sterols
Terpenes
Water Microbiology
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Summary:Abstract Actinobacteria are quotidian microorganisms in the marine world, playing a crucial ecological role in the recycling of refractory biomaterials and producing novel secondary metabolites with pharmaceutical applications. Actinobacteria have been isolated from the huge area of marine organisms including sponges, tunicates, corals, mollusks, crabs, mangroves and seaweeds. Natural products investigation of the marine actinobacteria revealed that they can synthesize numerous natural products including alkaloids, polyketides, peptides, isoprenoids, phenazines, sterols, and others. These natural products have a potential to provide future drugs against crucial diseases like cancer, HIV, microbial and protozoal infections and severe inflammations. Therefore, marine actinobacteria portray as a pivotal resource for marine drugs. It is an upcoming field of research to probe a novel and pharmaceutically important secondary metabolites from marine actinobacteria. In this review, we attempt to summarize the present knowledge on the diversity, chemistry and mechanism of action of marine actinobacteria-derived secondary metabolites from 2007 to 2016.
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2016.11.015