Platelet-rich plasma supplementation in arthroscopic repair of full-thickness rotator cuff tears: a randomized clinical trial

Background Results on the effectiveness of PRP supplementation in arthroscopic rotator cuff repair are conflicting, making it difficult to draw definitive conclusions. Methods This was a prospective, randomized, and double-blind study with two groups of 20 patients each (PRP group and control group)...

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Bibliographic Details
Published in:Musculoskeletal surgery 2016-12, Vol.100 (Suppl 1), p.25-32
Main Authors: D’Ambrosi, R., Palumbo, F., Paronzini, A., Ragone, V., Facchini, R. M.
Format: Article
Language:English
Subjects:
Aged
Arthroscopy - methods
Care and treatment
Clinical trials
Double-Blind Method
Female
Follow-Up Studies
Humans
Magnetic Resonance Imaging
Male
Medical research
Medicine
Medicine & Public Health
Medicine, Experimental
Middle Aged
Original Article
Orthopedic surgery
Orthopedics
Pain
Platelet-Rich Plasma
Prospective Studies
Range of Motion, Articular
Rotator Cuff Injuries - diagnostic imaging
Rotator Cuff Injuries - therapy
Surgical Orthopedics
Treatment Outcome
Wound Healing
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Summary:Background Results on the effectiveness of PRP supplementation in arthroscopic rotator cuff repair are conflicting, making it difficult to draw definitive conclusions. Methods This was a prospective, randomized, and double-blind study with two groups of 20 patients each (PRP group and control group). Degenerative supraspinatus full-thickness tears grade C2–C3 were subjected to arthroscopic repair; PRP supplementation was given to patients in the PRP group. The outcomes were assessed by DASH, Constant scales, and ultrasound before and 6 months after surgery. Pain measured by VAS was evaluated preoperatively and 7 and 30 days after surgery. Results The two groups did not differ significantly by age, sex, and dominance of the affected side. In all surgical procedures, a long head of the biceps tenotomy and single-row repair were performed. The preoperative VAS was 5.6 ± 2.4 in PRP group and 6.4 ± 1.5 in the control group ( p  > 0.05). The group supplemented with PRP reported a VAS significantly better in the first week (2.5 ± 1.9 vs 5.3 ± 2.1, p   0.05) in the control group. The average Constant score improved significantly after 6 months to 81 ± 11.2 ( p  
ISSN:2035-5106
2035-5114
DOI:10.1007/s12306-016-0415-2