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Platelet-rich plasma supplementation in arthroscopic repair of full-thickness rotator cuff tears: a randomized clinical trial
Background Results on the effectiveness of PRP supplementation in arthroscopic rotator cuff repair are conflicting, making it difficult to draw definitive conclusions. Methods This was a prospective, randomized, and double-blind study with two groups of 20 patients each (PRP group and control group)...
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| Published in: | Musculoskeletal surgery 2016-12, Vol.100 (Suppl 1), p.25-32 |
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| creator | D’Ambrosi, R. Palumbo, F. Paronzini, A. Ragone, V. Facchini, R. M. |
| description | Background
Results on the effectiveness of PRP supplementation in arthroscopic rotator cuff repair are conflicting, making it difficult to draw definitive conclusions.
Methods
This was a prospective, randomized, and double-blind study with two groups of 20 patients each (PRP group and control group). Degenerative supraspinatus full-thickness tears grade C2–C3 were subjected to arthroscopic repair; PRP supplementation was given to patients in the PRP group. The outcomes were assessed by DASH, Constant scales, and ultrasound before and 6 months after surgery. Pain measured by VAS was evaluated preoperatively and 7 and 30 days after surgery.
Results
The two groups did not differ significantly by age, sex, and dominance of the affected side. In all surgical procedures, a long head of the biceps tenotomy and single-row repair were performed. The preoperative VAS was 5.6 ± 2.4 in PRP group and 6.4 ± 1.5 in the control group (
p
> 0.05). The group supplemented with PRP reported a VAS significantly better in the first week (2.5 ± 1.9 vs 5.3 ± 2.1,
p
0.05) in the control group. The average Constant score improved significantly after 6 months to 81 ± 11.2 (
p
|
| doi_str_mv | 10.1007/s12306-016-0415-2 |
| format | article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1845249587</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A715473446</galeid><sourcerecordid>A715473446</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3542-7050d4c321d2a7daca2dbe50652722a515141e6ca1750e9011def2bd6aa00713</originalsourceid><addsrcrecordid>eNp1kU1vFSEUhidGY2v1B7gxJG7cTOUwMNzrrmn8SproontyLpxpqQyMwCxq4n-Xm1vrRzSEcALP--Yc3q57DvwUONevC4iBjz2HtiWoXjzojgUfVK8A5MP7mo9H3ZNSbjgf5UZtH3dHQm-bnvPj7vvngJUC1T57e82WgGVGVtZlCTRTrFh9isxHhrle51RsWrxlmRb0maWJTWsIfb329kukUlhOTZEys-s0sUqYyxuGLGN0afbfyDEbfPQWA6vZY3jaPZowFHp2d550l-_eXp5_6C8-vf94fnbR20FJ0WuuuJN2EOAEaocWhduR4qMSWghUoEACjRZBK05bDuBoEjs3IrYxYTjpXh1sl5y-rlSqmX2xFAJGSmsxsJFKyK3a6Ia-_Au9SWuOrbk9JTdSS4Bf1BUGMj5OqWa0e1NzpkFJPUg5Nur0H1RbjmZvU6TJt_s_BHAQ2PbTJdNkluxnzLcGuNknbg6Jm5a42SduRNO8uGt43c3k7hU_I26AOAClPcUryr9N9F_XHwbptXs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1844847411</pqid></control><display><type>article</type><title>Platelet-rich plasma supplementation in arthroscopic repair of full-thickness rotator cuff tears: a randomized clinical trial</title><source>Springer Nature</source><creator>D’Ambrosi, R. ; Palumbo, F. ; Paronzini, A. ; Ragone, V. ; Facchini, R. M.</creator><creatorcontrib>D’Ambrosi, R. ; Palumbo, F. ; Paronzini, A. ; Ragone, V. ; Facchini, R. M.</creatorcontrib><description><![CDATA[Background
Results on the effectiveness of PRP supplementation in arthroscopic rotator cuff repair are conflicting, making it difficult to draw definitive conclusions.
Methods
This was a prospective, randomized, and double-blind study with two groups of 20 patients each (PRP group and control group). Degenerative supraspinatus full-thickness tears grade C2–C3 were subjected to arthroscopic repair; PRP supplementation was given to patients in the PRP group. The outcomes were assessed by DASH, Constant scales, and ultrasound before and 6 months after surgery. Pain measured by VAS was evaluated preoperatively and 7 and 30 days after surgery.
Results
The two groups did not differ significantly by age, sex, and dominance of the affected side. In all surgical procedures, a long head of the biceps tenotomy and single-row repair were performed. The preoperative VAS was 5.6 ± 2.4 in PRP group and 6.4 ± 1.5 in the control group (
p
> 0.05). The group supplemented with PRP reported a VAS significantly better in the first week (2.5 ± 1.9 vs 5.3 ± 2.1,
p
< 0.05) and during the first month after surgery (1.5 ± 1.0 vs 3.2 ± 1.7,
p
< 0.05) compared to the control group. The preoperative Constant and DASH scores were 39.95 ± 12 and 51 ± 15.2, respectively, in the PRP group and 41 ± 11 (
p
> 0.05) and 45 ± 12.6 (
p
> 0.05) in the control group. The average Constant score improved significantly after 6 months to 81 ± 11.2 (
p
< 0.05) in the PRP group and 78.5 ± 9 (
p
< 0.05) in the control group. No differences were noted between the two groups (
p
> 0.05). The DASH score after 6 months was 17.4 ± 8 (
p
< 0.05) for the treatment group (the PRP group) and 21 ± 8.4 (
p
< 0.05) for the control group. No statistically significant differences were found as regards the DASH score in the two groups after 6 months (
p
> 0.05). The two groups showed no differences in the ultrasound evaluation after 6 months either. No re-ruptures occurred in either group.
Conclusions
PRP leads to a reduction in pain during a short-term follow-up. Pain reduction allows for a more rapid recovery of mobilization and improvement in functionality.
Level of evidence
Randomized controlled trial, Level of evidence, 1.]]></description><identifier>ISSN: 2035-5106</identifier><identifier>EISSN: 2035-5114</identifier><identifier>DOI: 10.1007/s12306-016-0415-2</identifier><identifier>PMID: 27900700</identifier><language>eng</language><publisher>Milan: Springer Milan</publisher><subject>Aged ; Arthroscopy - methods ; Care and treatment ; Clinical trials ; Double-Blind Method ; Female ; Follow-Up Studies ; Humans ; Magnetic Resonance Imaging ; Male ; Medical research ; Medicine ; Medicine & Public Health ; Medicine, Experimental ; Middle Aged ; Original Article ; Orthopedic surgery ; Orthopedics ; Pain ; Platelet-Rich Plasma ; Prospective Studies ; Range of Motion, Articular ; Rotator Cuff Injuries - diagnostic imaging ; Rotator Cuff Injuries - therapy ; Surgical Orthopedics ; Treatment Outcome ; Wound Healing</subject><ispartof>Musculoskeletal surgery, 2016-12, Vol.100 (Suppl 1), p.25-32</ispartof><rights>Istituto Ortopedico Rizzoli 2016</rights><rights>COPYRIGHT 2016 Springer</rights><rights>MUSCULOSKELETAL SURGERY is a copyright of Springer, 2016.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3542-7050d4c321d2a7daca2dbe50652722a515141e6ca1750e9011def2bd6aa00713</citedby><cites>FETCH-LOGICAL-c3542-7050d4c321d2a7daca2dbe50652722a515141e6ca1750e9011def2bd6aa00713</cites><orcidid>0000-0002-1216-792X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27900700$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>D’Ambrosi, R.</creatorcontrib><creatorcontrib>Palumbo, F.</creatorcontrib><creatorcontrib>Paronzini, A.</creatorcontrib><creatorcontrib>Ragone, V.</creatorcontrib><creatorcontrib>Facchini, R. M.</creatorcontrib><title>Platelet-rich plasma supplementation in arthroscopic repair of full-thickness rotator cuff tears: a randomized clinical trial</title><title>Musculoskeletal surgery</title><addtitle>Musculoskelet Surg</addtitle><addtitle>Musculoskelet Surg</addtitle><description><![CDATA[Background
Results on the effectiveness of PRP supplementation in arthroscopic rotator cuff repair are conflicting, making it difficult to draw definitive conclusions.
Methods
This was a prospective, randomized, and double-blind study with two groups of 20 patients each (PRP group and control group). Degenerative supraspinatus full-thickness tears grade C2–C3 were subjected to arthroscopic repair; PRP supplementation was given to patients in the PRP group. The outcomes were assessed by DASH, Constant scales, and ultrasound before and 6 months after surgery. Pain measured by VAS was evaluated preoperatively and 7 and 30 days after surgery.
Results
The two groups did not differ significantly by age, sex, and dominance of the affected side. In all surgical procedures, a long head of the biceps tenotomy and single-row repair were performed. The preoperative VAS was 5.6 ± 2.4 in PRP group and 6.4 ± 1.5 in the control group (
p
> 0.05). The group supplemented with PRP reported a VAS significantly better in the first week (2.5 ± 1.9 vs 5.3 ± 2.1,
p
< 0.05) and during the first month after surgery (1.5 ± 1.0 vs 3.2 ± 1.7,
p
< 0.05) compared to the control group. The preoperative Constant and DASH scores were 39.95 ± 12 and 51 ± 15.2, respectively, in the PRP group and 41 ± 11 (
p
> 0.05) and 45 ± 12.6 (
p
> 0.05) in the control group. The average Constant score improved significantly after 6 months to 81 ± 11.2 (
p
< 0.05) in the PRP group and 78.5 ± 9 (
p
< 0.05) in the control group. No differences were noted between the two groups (
p
> 0.05). The DASH score after 6 months was 17.4 ± 8 (
p
< 0.05) for the treatment group (the PRP group) and 21 ± 8.4 (
p
< 0.05) for the control group. No statistically significant differences were found as regards the DASH score in the two groups after 6 months (
p
> 0.05). The two groups showed no differences in the ultrasound evaluation after 6 months either. No re-ruptures occurred in either group.
Conclusions
PRP leads to a reduction in pain during a short-term follow-up. Pain reduction allows for a more rapid recovery of mobilization and improvement in functionality.
Level of evidence
Randomized controlled trial, Level of evidence, 1.]]></description><subject>Aged</subject><subject>Arthroscopy - methods</subject><subject>Care and treatment</subject><subject>Clinical trials</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Medicine, Experimental</subject><subject>Middle Aged</subject><subject>Original Article</subject><subject>Orthopedic surgery</subject><subject>Orthopedics</subject><subject>Pain</subject><subject>Platelet-Rich Plasma</subject><subject>Prospective Studies</subject><subject>Range of Motion, Articular</subject><subject>Rotator Cuff Injuries - diagnostic imaging</subject><subject>Rotator Cuff Injuries - therapy</subject><subject>Surgical Orthopedics</subject><subject>Treatment Outcome</subject><subject>Wound Healing</subject><issn>2035-5106</issn><issn>2035-5114</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNp1kU1vFSEUhidGY2v1B7gxJG7cTOUwMNzrrmn8SproontyLpxpqQyMwCxq4n-Xm1vrRzSEcALP--Yc3q57DvwUONevC4iBjz2HtiWoXjzojgUfVK8A5MP7mo9H3ZNSbjgf5UZtH3dHQm-bnvPj7vvngJUC1T57e82WgGVGVtZlCTRTrFh9isxHhrle51RsWrxlmRb0maWJTWsIfb329kukUlhOTZEys-s0sUqYyxuGLGN0afbfyDEbfPQWA6vZY3jaPZowFHp2d550l-_eXp5_6C8-vf94fnbR20FJ0WuuuJN2EOAEaocWhduR4qMSWghUoEACjRZBK05bDuBoEjs3IrYxYTjpXh1sl5y-rlSqmX2xFAJGSmsxsJFKyK3a6Ia-_Au9SWuOrbk9JTdSS4Bf1BUGMj5OqWa0e1NzpkFJPUg5Nur0H1RbjmZvU6TJt_s_BHAQ2PbTJdNkluxnzLcGuNknbg6Jm5a42SduRNO8uGt43c3k7hU_I26AOAClPcUryr9N9F_XHwbptXs</recordid><startdate>20161201</startdate><enddate>20161201</enddate><creator>D’Ambrosi, R.</creator><creator>Palumbo, F.</creator><creator>Paronzini, A.</creator><creator>Ragone, V.</creator><creator>Facchini, R. M.</creator><general>Springer Milan</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1216-792X</orcidid></search><sort><creationdate>20161201</creationdate><title>Platelet-rich plasma supplementation in arthroscopic repair of full-thickness rotator cuff tears: a randomized clinical trial</title><author>D’Ambrosi, R. ; Palumbo, F. ; Paronzini, A. ; Ragone, V. ; Facchini, R. M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3542-7050d4c321d2a7daca2dbe50652722a515141e6ca1750e9011def2bd6aa00713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Arthroscopy - methods</topic><topic>Care and treatment</topic><topic>Clinical trials</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Medicine, Experimental</topic><topic>Middle Aged</topic><topic>Original Article</topic><topic>Orthopedic surgery</topic><topic>Orthopedics</topic><topic>Pain</topic><topic>Platelet-Rich Plasma</topic><topic>Prospective Studies</topic><topic>Range of Motion, Articular</topic><topic>Rotator Cuff Injuries - diagnostic imaging</topic><topic>Rotator Cuff Injuries - therapy</topic><topic>Surgical Orthopedics</topic><topic>Treatment Outcome</topic><topic>Wound Healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>D’Ambrosi, R.</creatorcontrib><creatorcontrib>Palumbo, F.</creatorcontrib><creatorcontrib>Paronzini, A.</creatorcontrib><creatorcontrib>Ragone, V.</creatorcontrib><creatorcontrib>Facchini, R. M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Musculoskeletal surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>D’Ambrosi, R.</au><au>Palumbo, F.</au><au>Paronzini, A.</au><au>Ragone, V.</au><au>Facchini, R. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Platelet-rich plasma supplementation in arthroscopic repair of full-thickness rotator cuff tears: a randomized clinical trial</atitle><jtitle>Musculoskeletal surgery</jtitle><stitle>Musculoskelet Surg</stitle><addtitle>Musculoskelet Surg</addtitle><date>2016-12-01</date><risdate>2016</risdate><volume>100</volume><issue>Suppl 1</issue><spage>25</spage><epage>32</epage><pages>25-32</pages><issn>2035-5106</issn><eissn>2035-5114</eissn><abstract><![CDATA[Background
Results on the effectiveness of PRP supplementation in arthroscopic rotator cuff repair are conflicting, making it difficult to draw definitive conclusions.
Methods
This was a prospective, randomized, and double-blind study with two groups of 20 patients each (PRP group and control group). Degenerative supraspinatus full-thickness tears grade C2–C3 were subjected to arthroscopic repair; PRP supplementation was given to patients in the PRP group. The outcomes were assessed by DASH, Constant scales, and ultrasound before and 6 months after surgery. Pain measured by VAS was evaluated preoperatively and 7 and 30 days after surgery.
Results
The two groups did not differ significantly by age, sex, and dominance of the affected side. In all surgical procedures, a long head of the biceps tenotomy and single-row repair were performed. The preoperative VAS was 5.6 ± 2.4 in PRP group and 6.4 ± 1.5 in the control group (
p
> 0.05). The group supplemented with PRP reported a VAS significantly better in the first week (2.5 ± 1.9 vs 5.3 ± 2.1,
p
< 0.05) and during the first month after surgery (1.5 ± 1.0 vs 3.2 ± 1.7,
p
< 0.05) compared to the control group. The preoperative Constant and DASH scores were 39.95 ± 12 and 51 ± 15.2, respectively, in the PRP group and 41 ± 11 (
p
> 0.05) and 45 ± 12.6 (
p
> 0.05) in the control group. The average Constant score improved significantly after 6 months to 81 ± 11.2 (
p
< 0.05) in the PRP group and 78.5 ± 9 (
p
< 0.05) in the control group. No differences were noted between the two groups (
p
> 0.05). The DASH score after 6 months was 17.4 ± 8 (
p
< 0.05) for the treatment group (the PRP group) and 21 ± 8.4 (
p
< 0.05) for the control group. No statistically significant differences were found as regards the DASH score in the two groups after 6 months (
p
> 0.05). The two groups showed no differences in the ultrasound evaluation after 6 months either. No re-ruptures occurred in either group.
Conclusions
PRP leads to a reduction in pain during a short-term follow-up. Pain reduction allows for a more rapid recovery of mobilization and improvement in functionality.
Level of evidence
Randomized controlled trial, Level of evidence, 1.]]></abstract><cop>Milan</cop><pub>Springer Milan</pub><pmid>27900700</pmid><doi>10.1007/s12306-016-0415-2</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-1216-792X</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2035-5106 |
| ispartof | Musculoskeletal surgery, 2016-12, Vol.100 (Suppl 1), p.25-32 |
| issn | 2035-5106 2035-5114 |
| language | eng |
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| source | Springer Nature |
| subjects | Aged Arthroscopy - methods Care and treatment Clinical trials Double-Blind Method Female Follow-Up Studies Humans Magnetic Resonance Imaging Male Medical research Medicine Medicine & Public Health Medicine, Experimental Middle Aged Original Article Orthopedic surgery Orthopedics Pain Platelet-Rich Plasma Prospective Studies Range of Motion, Articular Rotator Cuff Injuries - diagnostic imaging Rotator Cuff Injuries - therapy Surgical Orthopedics Treatment Outcome Wound Healing |
| title | Platelet-rich plasma supplementation in arthroscopic repair of full-thickness rotator cuff tears: a randomized clinical trial |
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