Cognitive Performance in Subjects With Multiple Sclerosis Is Robustly Influenced by Gender in Canonical-Correlation Analysis

The authors explored the relations between clinical/demographic characteristics and performance on a neuropsychological battery (eight tests) in a cohort (N=46) of multiple sclerosis (MS) subjects. Findings resulted from a secondary analysis of a study examining the relationships between imaging bio...

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Bibliographic Details
Published in:The journal of neuropsychiatry and clinical neurosciences 2017-04, Vol.29 (2), p.119-127
Main Authors: Lin, Sue-Jin, Lam, Janet, Beveridge, Samantha, Vavasour, Irene, Traboulsee, Anthony, Li, David K.B, MacKay, Alex, McKeown, Martin, Kosaka, Brenda
Format: Article
Language:English
Subjects:
Adult
Cognition Disorders - diagnostic imaging
Cognition Disorders - etiology
Cohort Studies
Executive Function - physiology
Female
Humans
Male
Middle Aged
Multiple Sclerosis - complications
Multiple Sclerosis - diagnostic imaging
Neuropsychological Tests
Sex Characteristics
Statistics as Topic - methods
Young Adult
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Summary:The authors explored the relations between clinical/demographic characteristics and performance on a neuropsychological battery (eight tests) in a cohort (N=46) of multiple sclerosis (MS) subjects. Findings resulted from a secondary analysis of a study examining the relationships between imaging biomarkers in MS and cognitive tasks of executive functioning. The objective was to determine whether the overlapping test results could be judiciously combined and associated with clinical/demographic variables. Canonical-correlation analysis (CCA) was utilized, and it was found that differences between performance on untimed tests, and the sum of performance on timed Trail-Making Tests, Parts A and B, best matched clinical/demographic variables, and gender was the most important feature.
ISSN:0895-0172
1545-7222
DOI:10.1176/appi.neuropsych.16040083