Decreased Risk of Ventilator-Associated Pneumonia in Sepsis Due to Intra-Abdominal Infection: e0137262

Rationale Experimental studies suggest that intra-abdominal infection (IAI) induces biological alterations that may affect the risk of lung infection. Objectives To investigate the potential effect of IAI at ICU admission on the subsequent occurrence of ventilator-associated pneumonia (VAP). Methods...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2015-09, Vol.10 (9)
Main Authors: Philippart, Francois, Bouroche, Gaeelle, Timsit, Jean-Francois, Garrouste-Orgeas, Maite, Azoulay, Elie, Darmon, Michael, Adrie, Christophe, Allaouchiche, Bernard, Ara-Somohano, Claire, Ruckly, Stephane
Format: Article
Language:English
Subjects:
Enterobacteriaceae
Iais
Pseudomonas aeruginosa
Staphylococcus aureus
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Rationale Experimental studies suggest that intra-abdominal infection (IAI) induces biological alterations that may affect the risk of lung infection. Objectives To investigate the potential effect of IAI at ICU admission on the subsequent occurrence of ventilator-associated pneumonia (VAP). Methods We used data entered into the French prospective multicenter Outcomerea database in 1997-2011. Consecutive patients who had severe sepsis and/or septic shock at ICU admission and required mechanical ventilation for more than 3 days were included. Patients with acute pancreatitis were not included. Measurements and Main Results Of 2623 database patients meeting the inclusion criteria, 290 (11.1%) had IAI and 2333 (88.9%) had other infections. The IAI group had fewer patients with VAP (56 [19.3%] vs. 806 [34.5%], P
ISSN:1932-6203
DOI:10.1371/journal.pone.0137262