Inhibitory effect of stabilized analogues of glycoglycerolipids on Epstein–Barr virus activation and mouse skin tumor promotion

Nine new synthetic compounds, structurally related to the most active glycoglycerolipid analogues carrying a hexanoyl chain, were tested for their anti-tumor-promoting activity using a short-term in vitro assay for Epstein–Barr virus (EBV) activation. All these compounds, in which the ester function...

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Bibliographic Details
Published in:Cancer letters 2002-12, Vol.186 (1), p.37-41
Main Authors: Colombo, Diego, Compostella, Federica, Ronchetti, Fiamma, Reza-Elahi, Shahrzad, Scala, Antonio, Toma, Lucio, Aoi, Wataru, Kuchide, Masashi, Takayasu, Junko, Tokuda, Harukuni, Nishino, Hoyoku
Format: Article
Language:English
Subjects:
12- O-tetradecanoylphorbol-13-acetate
Animals
Anticarcinogenic Agents - pharmacology
Antineoplastic agents
Biological and medical sciences
Cancer chemoprevention
Chemotherapy
Cytotoxicity
Epstein-Barr virus
Experiments
Female
Glycerides - pharmacology
Glycerol
Glycoglycerolipids
Glycolipids - pharmacology
Herpesvirus 4, Human - drug effects
Herpesvirus 4, Human - physiology
Medical sciences
Mice
Mice, Inbred ICR
Papilloma - prevention & control
Pharmacology. Drug treatments
Rodents
Skin Neoplasms - prevention & control
Two-stage skin carcinogenesis test
Virus Activation - drug effects
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Summary:Nine new synthetic compounds, structurally related to the most active glycoglycerolipid analogues carrying a hexanoyl chain, were tested for their anti-tumor-promoting activity using a short-term in vitro assay for Epstein–Barr virus (EBV) activation. All these compounds, in which the ester function is replaced by different metabolically more stable groups, were almost as active as their ester reference compounds in inhibiting the EBV activation promoted by the tumor promoter 12- O-tetradecanoylphorbol-13-acetate (TPA). Two of these, devoid of any functionality on the lipophilic chain, when tested in an in vivo two-stage carcinogenesis test, exhibited marked inhibitory effects on mouse skin tumor promotion.
ISSN:0304-3835
1872-7980
DOI:10.1016/S0304-3835(02)00336-1