High-sensitivity C-reactive protein, apolipoproteins, and residual diuresis in chronic kidney disease patients undergoing hemodialysis

• Published in: Clinical and experimental nephrology 2016-12, Vol.20 (6), p.943-950
• Main Authors: Borges, Daniela Lemos, Lemes, Helton Pereira, de Castro Ferreira, Valéria, Filho, Sebastião Rodrigues Ferreira
• Format: Article
• Language: English
• Subjects: Adult; Aged; Apolipoproteins - blood; C-Reactive Protein - analysis; Cross-Sectional Studies; Diuresis; Female; Humans; Male; Medicine; Medicine & Public Health; Middle Aged; Nephrology; Original Article; Renal Dialysis; Renal Insufficiency, Chronic - blood; Renal Insufficiency, Chronic - physiopathology; Renal Insufficiency, Chronic - therapy; Serum Albumin - analysis; Urology
• ISSN: 1342-1751; 1437-7799
• DOI: 10.1007/s10157-016-1230-7

Background Residual diuresis (RD) is the simplest method for measuring renal residual function in patients with chronic kidney disease (CKD). A reduction in RD is associated with intensification of the inflammatory process caused by uremia. However, little is known regarding the relation between RD and inflammatory markers in these patients. We verify possible associations among the hs-CRP, atherogenic factors, and RD, in patients with CKD undergoing hemodialysis. Methods This study enrolled 80 patients with CKD undergoing hemodialysis. Patients were stratified according to RD in anuric (RD−) group ( n  = 47) and non-anuric (RD+) group ( n  = 33). Urine volumes were collected in a 24 h period during the interdialytic period. Serum high-sensitivity C-reactive protein (hs-CRP), and apolipoprotein (Apo) A1 and B levels were measured after fasting for 12 h. Results Serum hs-CRP levels were higher in the RD− group than in the RD+ group ( P  = 0.015). In the total group, hs-CRP was significantly correlated with RD ( r  = − 0.25, P  = 0.025) and Apo AI ( r  = − 0.25, P  = 0.024). A greater proportion of patients had reduced plasma concentrations of Apo AI in the RD− group (31.9 %) compared with the RD+ group (9.1 %) ( P  = 0.014). Conclusion This study shows a relationship between RD and the hs-CRP in patients undergoing hemodialysis. Although the inflammatory state was verified in a large part of the CKD population, patients without RD had more elevated hs-CRP serum levels than those with RD.