New insights into the antiangiogenic and proangiogenic properties of dietary polyphenols

• Published in: Molecular nutrition & food research 2017-06, Vol.61 (6), p.n/a
• Main Authors: Diniz, Carmen, Suliburska, Joanna, Ferreira, Isabel M.P.L.V.O.
• Format: Article
• Language: English
• Subjects: Angiogenesis; Angiogenesis Inducing Agents - pharmacology; Angiogenesis Inhibitors - pharmacology; Antiangiogenics; Anti‐angiogenic; Beverages; Cell proliferation; Cell Proliferation - drug effects; Diet; Dietary polyphenols; Dietary Supplements; Endothelial Cells - drug effects; Endothelial Cells - metabolism; Fruit - chemistry; Functional foods & nutraceuticals; Humans; Metabolites; Natural products; Polyphenols; Polyphenols - pharmacology; Proangiogenic; Signal Transduction; Structure–activity relationships; Vegetables; Vegetables - chemistry
• ISSN: 1613-4125; 1613-4133
• DOI: 10.1002/mnfr.201600912

Polyphenols can be found in natural products of plant origin, including vegetables, fruits, and beverages. A large number of these plant origin compounds are an integral part of the human diet and in the past decade evidence has shown their beneficial properties in human health, by acting in several cell signaling pathways. Among other beneficial effects, polyphenols have been associated with angiogenesis. Increasing evidence highlighting the ability of dietary polyphenols to influence angiogenesis by interfering with multiple signaling pathways is debated. Particular emphasis is given to the mechanisms that ultimately may induce the formation of capillary‐like structures (by increasing endothelial cell proliferation, migration, and invasion) or, conversely, may inhibit the steps of angiogenesis leading to the inhibition/regress of vascular development. Dietary polyphenols can, therefore, be viewed as promising nutraceuticals but important aspects have still to be further investigated, to deep knowledge concerning their concentration‐mediated effects, effect of specific polyphenols, and respective metabolites, to ensure their appropriate and effective usefulness as proangiogenic or antiangiogenic nutraceuticals. Polyphenols, which can be found in natural products that are part of the human diet, have been associated with angiogenesis. Increasing evidence highlighting the ability of dietary polyphenols to influence angiogenesis by interfering with multiple signaling pathways is debated. Particular emphasis is given to the mechanisms that ultimately may induce the formation of capillary‐like structures or, conversely, may inhibit the steps of angiogenesis. Dietary polyphenols can be viewed as promising nutraceuticals but important aspects have still to be further investigated.