Characterization of the nociceptive effect of carrageenan: Masseter versus gastrocnemius

ABSTRACT Introduction To better understand the pathophysiology of chronic muscle pain, there are multiple animal models that mimic different acute/chronic pain conditions, such as carrageenan injection. Our previous studies demonstrated differences between muscles of different innervation in acute p...

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Bibliographic Details
Published in:Muscle & nerve 2017-10, Vol.56 (4), p.804-813
Main Authors: Bagüés, Ana, Martín‐Fontelles, M. Isabel, Esteban‐Hernández, Jesús, Sánchez‐Robles, Eva M.
Format: Article
Language:English
Subjects:
Animal models
Animals
Carrageenan
Carrageenan - administration & dosage
Carrageenan - toxicity
Chronic pain
gastrocnemius
Hyperalgesia
Hyperalgesia - chemically induced
Hyperalgesia - pathology
Hypersensitivity
Injections, Intramuscular
Innervation
Male
masseter
Masseter Muscle - drug effects
Masseter Muscle - pathology
muscle pain
Muscle, Skeletal - drug effects
Muscle, Skeletal - pathology
Muscles
Pain
Pain Measurement - drug effects
Pain Measurement - methods
Pain perception
rat
Rats
Rats, Wistar
Rodents
Treatment Outcome
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Summary:ABSTRACT Introduction To better understand the pathophysiology of chronic muscle pain, there are multiple animal models that mimic different acute/chronic pain conditions, such as carrageenan injection. Our previous studies demonstrated differences between muscles of different innervation in acute pain. In this study we characterized the effect of carrageenan in 2 muscles: masseter (trigeminal innervation) and gastrocnemius (spinal innervation). Methods Carrageenan (3%, 6%, and 9%) was injected into the masseter and gastrocnemius of rats. Mechanical, heat, and chemical nociceptive thresholds were measured for 14 days. Results Carrageenan did not induce mechanical allodynia or thermal hypersensitivity in either muscle. Instead, it induced a short‐lasting mechanical hyperalgesia, greater in the masseter than in the gastrocnemius. Conclusion Carrageenan injected into the masseter and gastrocnemius induces a short‐lasting hyperalgesia. These results could indicate a higher susceptibility of orofacial muscles to this type of insult and, consequently, a difference between trigeminal and spinal innervation. Muscle Nerve 56: 804–813, 2017
ISSN:0148-639X
1097-4598
DOI:10.1002/mus.25538