Cross-sectional associations of objectively-measured physical activity with brain-derived neurotrophic factor in adolescents

Abstract Objective The purpose of this study was to examine the associations between objectively measured physical activity and serum brain-derived neurotrophic factor (BDNF) in adolescents. Methods Cross-sectional analyses were performed using data from 415 adolescents who participated in the 2015...

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Bibliographic Details
Published in:Physiology & behavior 2017-03, Vol.171, p.87-91
Main Authors: Huang, Tao, Gejl, Anne Kær, Tarp, Jakob, Andersen, Lars Bo, Peijs, Lone, Bugge, Anna
Format: Article
Language:English
Subjects:
Accelerometry
Adolescent
Adolescents
Anthropometry
Brain-derived neurotrophic factor
Brain-Derived Neurotrophic Factor - blood
Cross-Sectional Studies
Enzyme-Linked Immunosorbent Assay
Exercise - physiology
Female
Humans
Male
Moderate to vigorous physical activity
Motor Activity
Physical activity
Psychiatry
Sedentary Lifestyle
Sexual Maturation - physiology
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Summary:Abstract Objective The purpose of this study was to examine the associations between objectively measured physical activity and serum brain-derived neurotrophic factor (BDNF) in adolescents. Methods Cross-sectional analyses were performed using data from 415 adolescents who participated in the 2015 follow-up of the Childhood Health Activity and Motor Performance School Study Denmark (the CHAMPS-study DK). Physical activity was objectively measured by accelerometry monitors. Serum BDNF levels were analyzed using the Enzyme-linked immunosorbent assay (ELISA). Anthropometrics and pubertal status were measured using standardized procedures. Results With adjustment for age, pubertal status and body mass index, mean physical activity (counts per minute) was negatively associated with serum BDNF in boys ( P = 0.013). Similarly, moderate-to-vigorous physical activity (MVPA) was negatively associated with serum BDNF in boys ( P = 0.035). In girls, mean physical activity and MVPA were not associated with serum BDNF. Without adjustment for wear time, sedentary time was not associated with serum BDNF in either sex. Conclusion These findings indicate that higher physical activity is associated with lower serum BDNF in boys, but not in girls.
ISSN:0031-9384
1873-507X
DOI:10.1016/j.physbeh.2016.12.026