African swine fever virus serotype-specific proteins are significant protective antigens for African swine fever

African swine fever (ASF) is an emerging disease threat for the swine industry worldwide. No ASF vaccine is available and progress is hindered by lack of knowledge concerning the extent of ASFV strain diversity and the viral antigens conferring type-specific protective immunity in pigs. Available da...

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Published in:Journal of general virology 2016-07, Vol.97 (7), p.1670-1675
Main Authors: Burmakina, G, Malogolovkin, A, Tulman, E R, Zsak, L, Delhon, G, Diel, D G, Shobogorov, N M, Morgunov, Yu P, Morgunov, S Yu, Kutish, G F, Kolbasov, D, Rock, D L
Format: Article
Language:English
Subjects:
African Swine Fever - immunology
African Swine Fever - prevention & control
African Swine Fever - virology
African Swine Fever Virus - immunology
Animals
Antibodies, Viral - blood
Antibodies, Viral - immunology
Antigens, Viral - immunology
Flaviviridae
Lectins, C-Type - immunology
Serogroup
Swine - virology
Swine Diseases - prevention & control
Swine Diseases - virology
Vaccination
Viral Proteins - immunology
Viral Vaccines - immunology
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Summary:African swine fever (ASF) is an emerging disease threat for the swine industry worldwide. No ASF vaccine is available and progress is hindered by lack of knowledge concerning the extent of ASFV strain diversity and the viral antigens conferring type-specific protective immunity in pigs. Available data from vaccination/challenge experiments in pigs indicate that ASF protective immunity may be haemadsorption inhibition (HAI) serotype-specific. Recently, we have shown that two ASFV proteins, CD2v (EP402R) and C-type lectin (EP153R), are necessary and sufficient for mediating HAI serological specificity (Malogolovkin et al., 2015).. Here, using ASFV inter-serotypic chimeric viruses and vaccination/challenge experiments in pigs, we demonstrate that serotype-specific CD2v and/or C-type lectin proteins are important for protection against homologous ASFV infection. Thus, these viral proteins represent significant protective antigens for ASFV that should be targeted in future vaccine design and development. Additionally, these data support the concept of HAI serotype-specific protective immunity.
ISSN:0022-1317
1465-2099
DOI:10.1099/jgv.0.000490