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Clinical usefulness of international normalized ratio calibration of prothrombin time in patients with chronic liver disease
The international normalized ratio (INR) may not be directly applicable to patients with liver disease. We aimed to establish an alternative INR calibration system for patients with liver disease and to evaluate the effect of their use in chronic liver disease patients. Eighty-two patients with live...
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| Published in: | International journal of hematology 2015-08, Vol.102 (2), p.163-169 |
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| Main Authors: | , , , , , |
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| container_end_page | 169 |
| container_issue | 2 |
| container_start_page | 163 |
| container_title | International journal of hematology |
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| creator | Lee, Jun Hyung Kweon, Oh Joo Lee, Mi-Kyung Lee, Hyun Woong Kim, Hyung Joon Kim, Hye Ryoun |
| description | The international normalized ratio (INR) may not be directly applicable to patients with liver disease. We aimed to establish an alternative INR calibration system for patients with liver disease and to evaluate the effect of their use in chronic liver disease patients. Eighty-two patients with liver cirrhosis (LC) were included, and their prothrombin times (PTs) were measured by using 5 commercial thromboplastins. Each of the thromboplastins was also assigned an international sensitivity index (ISI
liver
) by the plasmas from LC patients. INR
vka
, INR
liver
, model for end-stage liver disease (MELD)
vka
, MELD
liver
, Child-Pugh (Child)
vka
, and Child
liver
scores were calculated. The coefficient of variance of INR
vka
was significantly larger than that of INR
liver
(
P
|
| doi_str_mv | 10.1007/s12185-015-1820-2 |
| format | article |
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liver
) by the plasmas from LC patients. INR
vka
, INR
liver
, model for end-stage liver disease (MELD)
vka
, MELD
liver
, Child-Pugh (Child)
vka
, and Child
liver
scores were calculated. The coefficient of variance of INR
vka
was significantly larger than that of INR
liver
(
P
< 0.01). The mean difference in INR
vka
between the thromboplastins was also significantly larger than that in INR
liver
(
P
< 0.01). The total mean MELD
liver
score was higher than the total mean MELD
vka
score. The mean difference between the MELD
vka
and MELD
liver
scores (MELD score ≥15) was 3.2 %. We reconfirmed that the use of the alternative calibration system described herein for patients with liver disease may resolve the variability of INR measurement. Our data suggest that we would need to reevaluate the correlation between Child-Pugh class, MELD score, and clinical prognosis by using INR
liver
for patients with LC.</description><identifier>ISSN: 0925-5710</identifier><identifier>EISSN: 1865-3774</identifier><identifier>DOI: 10.1007/s12185-015-1820-2</identifier><identifier>PMID: 26068391</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Aged ; Chronic Disease ; Female ; Hematology ; Humans ; International Normalized Ratio ; Liver Cirrhosis - blood ; Liver Cirrhosis - etiology ; Liver Diseases - blood ; Liver Diseases - diagnosis ; Liver Diseases - etiology ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Oncology ; Original Article ; Prothrombin Time - methods ; Prothrombin Time - standards ; Reference Values ; Thromboplastin</subject><ispartof>International journal of hematology, 2015-08, Vol.102 (2), p.163-169</ispartof><rights>The Japanese Society of Hematology 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-9f0b0482618b8667356edc4d08cbe3851a733d799128db00d2fe35a1ee7dfc2d3</citedby><cites>FETCH-LOGICAL-c499t-9f0b0482618b8667356edc4d08cbe3851a733d799128db00d2fe35a1ee7dfc2d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26068391$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Jun Hyung</creatorcontrib><creatorcontrib>Kweon, Oh Joo</creatorcontrib><creatorcontrib>Lee, Mi-Kyung</creatorcontrib><creatorcontrib>Lee, Hyun Woong</creatorcontrib><creatorcontrib>Kim, Hyung Joon</creatorcontrib><creatorcontrib>Kim, Hye Ryoun</creatorcontrib><title>Clinical usefulness of international normalized ratio calibration of prothrombin time in patients with chronic liver disease</title><title>International journal of hematology</title><addtitle>Int J Hematol</addtitle><addtitle>Int J Hematol</addtitle><description>The international normalized ratio (INR) may not be directly applicable to patients with liver disease. We aimed to establish an alternative INR calibration system for patients with liver disease and to evaluate the effect of their use in chronic liver disease patients. Eighty-two patients with liver cirrhosis (LC) were included, and their prothrombin times (PTs) were measured by using 5 commercial thromboplastins. Each of the thromboplastins was also assigned an international sensitivity index (ISI
liver
) by the plasmas from LC patients. INR
vka
, INR
liver
, model for end-stage liver disease (MELD)
vka
, MELD
liver
, Child-Pugh (Child)
vka
, and Child
liver
scores were calculated. The coefficient of variance of INR
vka
was significantly larger than that of INR
liver
(
P
< 0.01). The mean difference in INR
vka
between the thromboplastins was also significantly larger than that in INR
liver
(
P
< 0.01). The total mean MELD
liver
score was higher than the total mean MELD
vka
score. The mean difference between the MELD
vka
and MELD
liver
scores (MELD score ≥15) was 3.2 %. We reconfirmed that the use of the alternative calibration system described herein for patients with liver disease may resolve the variability of INR measurement. Our data suggest that we would need to reevaluate the correlation between Child-Pugh class, MELD score, and clinical prognosis by using INR
liver
for patients with LC.</description><subject>Aged</subject><subject>Chronic Disease</subject><subject>Female</subject><subject>Hematology</subject><subject>Humans</subject><subject>International Normalized Ratio</subject><subject>Liver Cirrhosis - blood</subject><subject>Liver Cirrhosis - etiology</subject><subject>Liver Diseases - blood</subject><subject>Liver Diseases - diagnosis</subject><subject>Liver Diseases - etiology</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Prothrombin Time - methods</subject><subject>Prothrombin Time - standards</subject><subject>Reference Values</subject><subject>Thromboplastin</subject><issn>0925-5710</issn><issn>1865-3774</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNqFkUFrFjEQhoMo9mv1B3iRgJdetk6SzSZ7LB-tFQpe9Byym1mbks1-TXYVS3-8WbdKEcRThrzPOzPMS8gbBmcMQL3PjDMtK2CyYppDxZ-RHdONrIRS9XOyg5bLSioGR-Q451sApqBWL8kRb6DRomU78rAPPvreBrpkHJYQMWc6DdTHGVO0s59i0eKURhv8PTqa1j9aDL77VcaVPqRpvknT2PlIZz9isdNDUTHOmX738w3ti1zm0OC_YaLOZ7QZX5EXgw0ZXz--J-TL5cXn_VV1_enDx_35ddXXbTtX7QAd1Jo3THe6aZSQDbq-dqD7DoWWzCohnGpbxrXrABwfUEjLEJUbeu7ECTnd-pY97xbMsxl97jEEG3FasilHlKBkzfn_UQW8kTUIXdB3f6G301JuFjaKtYprWSi2UX2ack44mEPyo00_DAOzpmi2FE1J0awpmnWJt4-dl25E98fxO7YC8A3IRYpfMT0Z_c-uPwE2dqkH</recordid><startdate>20150801</startdate><enddate>20150801</enddate><creator>Lee, Jun Hyung</creator><creator>Kweon, Oh Joo</creator><creator>Lee, Mi-Kyung</creator><creator>Lee, Hyun Woong</creator><creator>Kim, Hyung Joon</creator><creator>Kim, Hye Ryoun</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7U7</scope></search><sort><creationdate>20150801</creationdate><title>Clinical usefulness of international normalized ratio calibration of prothrombin time in patients with chronic liver disease</title><author>Lee, Jun Hyung ; Kweon, Oh Joo ; Lee, Mi-Kyung ; Lee, Hyun Woong ; Kim, Hyung Joon ; Kim, Hye Ryoun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-9f0b0482618b8667356edc4d08cbe3851a733d799128db00d2fe35a1ee7dfc2d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Chronic Disease</topic><topic>Female</topic><topic>Hematology</topic><topic>Humans</topic><topic>International Normalized Ratio</topic><topic>Liver Cirrhosis - blood</topic><topic>Liver Cirrhosis - etiology</topic><topic>Liver Diseases - blood</topic><topic>Liver Diseases - diagnosis</topic><topic>Liver Diseases - etiology</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Prothrombin Time - methods</topic><topic>Prothrombin Time - standards</topic><topic>Reference Values</topic><topic>Thromboplastin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Jun Hyung</creatorcontrib><creatorcontrib>Kweon, Oh Joo</creatorcontrib><creatorcontrib>Lee, Mi-Kyung</creatorcontrib><creatorcontrib>Lee, Hyun Woong</creatorcontrib><creatorcontrib>Kim, Hyung Joon</creatorcontrib><creatorcontrib>Kim, Hye Ryoun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Toxicology Abstracts</collection><jtitle>International journal of hematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Jun Hyung</au><au>Kweon, Oh Joo</au><au>Lee, Mi-Kyung</au><au>Lee, Hyun Woong</au><au>Kim, Hyung Joon</au><au>Kim, Hye Ryoun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical usefulness of international normalized ratio calibration of prothrombin time in patients with chronic liver disease</atitle><jtitle>International journal of hematology</jtitle><stitle>Int J Hematol</stitle><addtitle>Int J Hematol</addtitle><date>2015-08-01</date><risdate>2015</risdate><volume>102</volume><issue>2</issue><spage>163</spage><epage>169</epage><pages>163-169</pages><issn>0925-5710</issn><eissn>1865-3774</eissn><abstract>The international normalized ratio (INR) may not be directly applicable to patients with liver disease. We aimed to establish an alternative INR calibration system for patients with liver disease and to evaluate the effect of their use in chronic liver disease patients. Eighty-two patients with liver cirrhosis (LC) were included, and their prothrombin times (PTs) were measured by using 5 commercial thromboplastins. Each of the thromboplastins was also assigned an international sensitivity index (ISI
liver
) by the plasmas from LC patients. INR
vka
, INR
liver
, model for end-stage liver disease (MELD)
vka
, MELD
liver
, Child-Pugh (Child)
vka
, and Child
liver
scores were calculated. The coefficient of variance of INR
vka
was significantly larger than that of INR
liver
(
P
< 0.01). The mean difference in INR
vka
between the thromboplastins was also significantly larger than that in INR
liver
(
P
< 0.01). The total mean MELD
liver
score was higher than the total mean MELD
vka
score. The mean difference between the MELD
vka
and MELD
liver
scores (MELD score ≥15) was 3.2 %. We reconfirmed that the use of the alternative calibration system described herein for patients with liver disease may resolve the variability of INR measurement. Our data suggest that we would need to reevaluate the correlation between Child-Pugh class, MELD score, and clinical prognosis by using INR
liver
for patients with LC.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>26068391</pmid><doi>10.1007/s12185-015-1820-2</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0925-5710 |
| ispartof | International journal of hematology, 2015-08, Vol.102 (2), p.163-169 |
| issn | 0925-5710 1865-3774 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1855075422 |
| source | Springer Nature |
| subjects | Aged Chronic Disease Female Hematology Humans International Normalized Ratio Liver Cirrhosis - blood Liver Cirrhosis - etiology Liver Diseases - blood Liver Diseases - diagnosis Liver Diseases - etiology Male Medicine Medicine & Public Health Middle Aged Oncology Original Article Prothrombin Time - methods Prothrombin Time - standards Reference Values Thromboplastin |
| title | Clinical usefulness of international normalized ratio calibration of prothrombin time in patients with chronic liver disease |
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