Basal rate tests (24‐hour fasts) performed in type‐1 diabetic subjects with either absolute fasting or snacks containing negligible carbohydrate amounts result in similar glucose profiles: A randomized controlled prospective trial

Aims Basal rate tests (24‐hour fasting periods) may be necessary to optimize basal insulin replacement in type 1 diabetes. It was the aim of this study to prospectively compare the allowance of negligible carbohydrate snacks vs absolute fasting. Methods A total of 20 patients with type 1 diabetes (a...

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Bibliographic Details
Published in:Diabetes, obesity & metabolism obesity & metabolism, 2017-06, Vol.19 (6), p.783-790
Main Authors: Haase, Maike, Kahle, Melanie, Janert, Martin, Meier, Juris J., Nauck, Michael A.
Format: Article
Language:English
Subjects:
Adult
basal insulin replacement
Basal Metabolism - physiology
basal rate test
Blood Glucose - analysis
Body weight
Carbohydrates
Diabetes
Diabetes mellitus
Diabetes Mellitus, Type 1 - blood
Diabetes Mellitus, Type 1 - complications
Diabetes Mellitus, Type 1 - metabolism
Dietary Carbohydrates - administration & dosage
Evidence-based medicine
Fasting
Fasting - metabolism
Female
Glucose
Humans
hypoglycaemia
Hypoglycemia - blood
Hypoglycemia - etiology
Hypoglycemia - metabolism
Insulin
Insulin - blood
intensified insulin regimen
Laboratory testing
Male
Middle Aged
multiple daily insulin injections
Prospective Studies
Snacks - physiology
type 1 diabetes
Vegetables
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Summary:Aims Basal rate tests (24‐hour fasting periods) may be necessary to optimize basal insulin replacement in type 1 diabetes. It was the aim of this study to prospectively compare the allowance of negligible carbohydrate snacks vs absolute fasting. Methods A total of 20 patients with type 1 diabetes (age, 48 ± 15 years (9 women, 11 men); BMI, 28.5 ± 4.5 kg/m2; HbA1c, 8.8% ± 2.0% (73.0 ± 21.9 mmol/mol); insulin dose, 0.69 ± 0.31 IU/kg body weight and per day) participated in 2 basal rate tests lasting 24 hours in random order with unchanged basal insulin replacement. On 1 occasion, negligible carbohydrate snacks (salads and vegetables, up to 5.1 g carbohydrate and 276.3 kJ per portion) were allowed; during the second test subjects were obliged to fast absolutely. Plasma glucose profiles were determined using an exact laboratory method. Hypoglycaemic episodes (plasma glucose 
ISSN:1462-8902
1463-1326
DOI:10.1111/dom.12868