Percutaneous renal artery embolisation of non-functioning renal allografts with clinical intolerance

• Published in: Transplant international 2002-04, Vol.15 (4), p.149-155
• Main Authors: Cofan, Federico, Maria-Isabel Real, Vilardell, Jordi, Montanya, Xavier, Blasco, Jordi, Martin, Pilar, Oppenheimer, Federico, Gutierrez, Rafael, Talbot-Wright, Roberto, Alcover, Juan
• Format: Article
• Language: English
• ISSN: 0934-0874; 1432-2277
• DOI: 10.1007/s00147-002-0390-4

The aim of the study was to evaluate the efficacy and safety of percutaneous renal artery embolisation of non-functioning renal allografts in patients with graft intolerance syndrome (GIS). Transcatheter artery embolisation was performed in 30 kidney transplant recipients with GIS. The duration of graft function had been 60±45 months. Infectious disease was ruled out in all patients. Embolisation consisted of the injection of polyvinyl alcohol microspheres followed by the insertion of a stainless steel coil in the renal artery branches. Symptoms of GIS included: fever-graft pain (44%, n=13), fever-hematuria-pain (20%, n=6), fever-hematuria (13%, n=4) and fever alone (23%, n=7). Latency time between graft failure and embolisation was 184±227 (17-1181) days. Embolisation was clinically successful with the prolonged disappearance of GIS in 24 patients (80%). Six patients showed initial clinical improvement, but GIS reappeared at 40±18 days, and graft nephrectomy was required. There were no major complications associated with embolisation and no deaths. Perirenal collateral supply was a risk factor for the reappearance of GIS. Renal vascular embolisation is a simple, safe and effective technique for treating renal allograft intolerance syndrome and could be a feasible alternative for the first-line treatment.