Enantiomer separation of 7-des-methyl-ormeloxifene using sulfated β-cyclodextrin in countercurrent chromatography

The enantiomers of 7‐des‐methyl‐ormeloxifene were separated by countercurrent chromatography (CCC) using sulfated β‐cyclodextrin as chiral selector, representing the first reported successful application of a cyclodextrin derivative in CCC‐based resolutions. The choice of chiral selector relies on e...

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Bibliographic Details
Published in:Chirality (New York, N.Y.) N.Y.), 1999, Vol.11 (10), p.768-771
Main Authors: Breinholt, Jens, Lehmann, Søren Vig, Varming, Annemarie Reinhardt
Format: Article
Language:English
Subjects:
capillary electrophoresis
chiral CCC
chiral separation
countercurrent chromatography
sulfated β-cyclodextrin
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Summary:The enantiomers of 7‐des‐methyl‐ormeloxifene were separated by countercurrent chromatography (CCC) using sulfated β‐cyclodextrin as chiral selector, representing the first reported successful application of a cyclodextrin derivative in CCC‐based resolutions. The choice of chiral selector relies on extreme separation factors observed in chiral capillary electrophoresis, and suitable CCC conditions were developed employing an analytical toroidal coil countercurrent chromatograph. Preparative separation of the enantiomers was performed using a conventional, preparative CCC‐instrument. Chirality 11:768–771, 1999. © 1999 Wiley‐Liss, Inc.
ISSN:0899-0042
1520-636X
DOI:10.1002/(SICI)1520-636X(1999)11:10<768::AID-CHIR5>3.0.CO;2-E