Physical stabilization of DNA-based therapeutics

The development of non-viral vectors for gene delivery has primarily focused on improving the efficiency of gene transfer in vivo. Although there is clearly a need to improve delivery efficiency, studies also indicate that the physical stability of non-viral vectors is not nearly adequate for a mark...

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Bibliographic Details
Published in:Drug Discovery Today 2001-05, Vol.6 (9), p.463-470
Main Authors: Anchordoquy, Thomas J, Allison, S.Dean, Molina, Marion d.C, Girouard, Lorinda G, Carson, Taylor K
Format: Article
Language:English
Subjects:
Biological and medical sciences
cationic liposome
cryoprotection
drying
formulation
freezing
gene delivery
General pharmacology
lyophilization
Medical sciences
nonviral vector
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
slability
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Summary:The development of non-viral vectors for gene delivery has primarily focused on improving the efficiency of gene transfer in vivo. Although there is clearly a need to improve delivery efficiency, studies also indicate that the physical stability of non-viral vectors is not nearly adequate for a marketable pharmaceutical product. Here, we describe the different strategies that have been used to enhance stability and discuss the mechanisms by which prolonged stabilization (>2 years) might be achieved.
ISSN:1359-6446
1878-5832
DOI:10.1016/S1359-6446(01)01739-1