Evaluation of in utero exposure to arsenic in South Africa

Early life exposure to inorganic arsenic (iAs) has been shown to interfere with foetal and early childhood development, and is associated with morbidity and mortality in adulthood. The purpose of this study was to evaluate exposure to As in utero, to determine the association between maternal and co...

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Bibliographic Details
Published in:The Science of the total environment 2017-01, Vol.575, p.338-346
Main Authors: Röllin, Halina B., Channa, Kalavati, Olutola, Bukola G., Odland, Jon Ø.
Format: Article
Language:English
Subjects:
Arsenic
Arsenic - blood
Arsenic sources
Biological monitoring
Birth outcomes
Drinking Water - chemistry
Female
Fetal Blood - chemistry
Humans
In utero exposure
Infant, Newborn
Maternal Exposure
Placental transfer
Pregnancy
South Africa
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Summary:Early life exposure to inorganic arsenic (iAs) has been shown to interfere with foetal and early childhood development, and is associated with morbidity and mortality in adulthood. The purpose of this study was to evaluate exposure to As in utero, to determine the association between maternal and cord blood of As and birth outcomes in South African populations. Total arsenic was measured in maternal blood of a total cohort (n=650) and in paired cord blood and urine of a subset cohort (n=317). Overall, the geometric mean (GM) of As in maternal blood was 0.62μg/L (n=650; 95% CI, 0.58–0.66). In the subset cohort, the GM of maternal blood As was 0.96μg/L (n=350; 95% CI, 0.91–1.02); in paired cord blood, the GM was 0.78μg/L (n=317; 95% CI, 0.74–0.83); and in urine (creatinine–corrected), the GM was 14.26μg/g creatinine (n=317; 95% CI, 12.64–16.09). A linear correlation was found between log maternal blood As and log cord blood As (rho=0.80, p
ISSN:0048-9697
1879-1026
DOI:10.1016/j.scitotenv.2016.10.044