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Effect of probiotics and synbiotics on blood glucose: a systematic review and meta-analysis of controlled trials
Purpose High fasting blood glucose (FBG) can lead to chronic diseases such as diabetes mellitus, cardiovascular and kidney diseases. Consuming probiotics or synbiotics may improve FBG. A systematic review and meta-analysis of controlled trials was conducted to clarify the effect of probiotic and syn...
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| Published in: | European journal of nutrition 2018-02, Vol.57 (1), p.95-106 |
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| container_end_page | 106 |
| container_issue | 1 |
| container_start_page | 95 |
| container_title | European journal of nutrition |
| container_volume | 57 |
| creator | Nikbakht, Elham Khalesi, Saman Singh, Indu Williams, Lauren Therese West, Nicholas P. Colson, Natalie |
| description | Purpose
High fasting blood glucose (FBG) can lead to chronic diseases such as diabetes mellitus, cardiovascular and kidney diseases. Consuming probiotics or synbiotics may improve FBG. A systematic review and meta-analysis of controlled trials was conducted to clarify the effect of probiotic and synbiotic consumption on FBG levels.
Methods
PubMed, Scopus, Cochrane Library, and Cumulative Index to Nursing and Allied Health Literature databases were searched for relevant studies based on eligibility criteria. Randomized or non-randomized controlled trials which investigated the efficacy of probiotics or synbiotics on the FBG of adults were included. Studies were excluded if they were review articles and study protocols, or if the supplement dosage was not clearly mentioned.
Results
A total of fourteen studies (eighteen trials) were included in the analysis. Random-effects meta-analyses were conducted for the mean difference in FBG. Overall reduction in FBG observed from consumption of probiotics and synbiotics was borderline statistically significant (−0.18 mmol/L 95 % CI −0.37, 0.00;
p
= 0.05). Neither probiotic nor synbiotic subgroup analysis revealed a significant reduction in FBG. The result of subgroup analysis for baseline FBG level ≥7 mmol/L showed a reduction in FBG of 0.68 mmol/L (−1.07, −0.29
; ρ
|
| doi_str_mv | 10.1007/s00394-016-1300-3 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1859718362</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2007039246</sourcerecordid><originalsourceid>FETCH-LOGICAL-c438t-df5382afdb03537ae59e6f5c7dc4116b90123c8c81f486cddfb7af45193cb3d43</originalsourceid><addsrcrecordid>eNp1UctKxDAUDaI44-gHuJGAGzfVPNq0dSfD-IABN7oOaR5Dh7YZc1tl_t6M8xAEVzfhPC73HIQuKbmlhOR3QAgv04RQkVBOSMKP0JimXCSC0ez48Cb5CJ0BLAkhjAt6ikYsz0qSs3KMVjPnrO6xd3gVfFX7vtaAVWcwrLv913e4arw3eNEM2oO9xyrC0NtWRRwH-1nbrx9Ra3uVqE41a6hhY6p91wffNNbgPtSqgXN04uKwF7s5Qe-Ps7fpczJ_fXqZPswTnfKiT4zLeMGUMxXhGc-VzUorXKZzo1NKRVUSyrgudEFdWghtjKty5dKMllxX3KR8gm62vvGsj8FCL9satG0a1Vk_gKRFVua04IJF6vUf6tIPIR4BksWYY8YsFZFFtywdPECwTq5C3aqwlpTITR1yW4eMdchNHZJHzdXOeahaaw6Kff6RwLYEiFC3sOF39f-u36qoljc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2007039246</pqid></control><display><type>article</type><title>Effect of probiotics and synbiotics on blood glucose: a systematic review and meta-analysis of controlled trials</title><source>Springer Nature</source><source>SPORTDiscus with Full Text</source><creator>Nikbakht, Elham ; Khalesi, Saman ; Singh, Indu ; Williams, Lauren Therese ; West, Nicholas P. ; Colson, Natalie</creator><creatorcontrib>Nikbakht, Elham ; Khalesi, Saman ; Singh, Indu ; Williams, Lauren Therese ; West, Nicholas P. ; Colson, Natalie</creatorcontrib><description>Purpose
High fasting blood glucose (FBG) can lead to chronic diseases such as diabetes mellitus, cardiovascular and kidney diseases. Consuming probiotics or synbiotics may improve FBG. A systematic review and meta-analysis of controlled trials was conducted to clarify the effect of probiotic and synbiotic consumption on FBG levels.
Methods
PubMed, Scopus, Cochrane Library, and Cumulative Index to Nursing and Allied Health Literature databases were searched for relevant studies based on eligibility criteria. Randomized or non-randomized controlled trials which investigated the efficacy of probiotics or synbiotics on the FBG of adults were included. Studies were excluded if they were review articles and study protocols, or if the supplement dosage was not clearly mentioned.
Results
A total of fourteen studies (eighteen trials) were included in the analysis. Random-effects meta-analyses were conducted for the mean difference in FBG. Overall reduction in FBG observed from consumption of probiotics and synbiotics was borderline statistically significant (−0.18 mmol/L 95 % CI −0.37, 0.00;
p
= 0.05). Neither probiotic nor synbiotic subgroup analysis revealed a significant reduction in FBG. The result of subgroup analysis for baseline FBG level ≥7 mmol/L showed a reduction in FBG of 0.68 mmol/L (−1.07, −0.29
; ρ
< 0.01), while trials with multiple species of probiotics showed a more pronounced reduction of 0.31 mmol/L (−0.58, −0.03;
ρ
=
0.03)
compared to single species trials.
Conclusion
This meta-analysis suggests that probiotic and synbiotic supplementation may be beneficial in lowering FBG in adults with high baseline FBG (≥7 mmol/L) and that multispecies probiotics may have more impact on FBG than single species.</description><identifier>ISSN: 1436-6207</identifier><identifier>EISSN: 1436-6215</identifier><identifier>DOI: 10.1007/s00394-016-1300-3</identifier><identifier>PMID: 27590729</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adolescent ; Adult ; Aged ; Blood Glucose - analysis ; Chemistry ; Chemistry and Materials Science ; Chronic illnesses ; Controlled Clinical Trials as Topic ; Diabetes mellitus ; Evidence-based medicine ; Fasting ; Humans ; Hyperglycemia ; Hyperglycemia - prevention & control ; MEDLINE ; Meta-analysis ; Middle Aged ; Nursing ; Nutrition ; Original Contribution ; Probiotics ; Probiotics - administration & dosage ; Randomized Controlled Trials as Topic ; Reviews ; Species ; Statistical analysis ; Supplements ; Synbiotics - administration & dosage ; Systematic review</subject><ispartof>European journal of nutrition, 2018-02, Vol.57 (1), p.95-106</ispartof><rights>Springer-Verlag Berlin Heidelberg 2016</rights><rights>European Journal of Nutrition is a copyright of Springer, (2016). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-df5382afdb03537ae59e6f5c7dc4116b90123c8c81f486cddfb7af45193cb3d43</citedby><cites>FETCH-LOGICAL-c438t-df5382afdb03537ae59e6f5c7dc4116b90123c8c81f486cddfb7af45193cb3d43</cites><orcidid>0000-0002-8208-2518</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27590729$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nikbakht, Elham</creatorcontrib><creatorcontrib>Khalesi, Saman</creatorcontrib><creatorcontrib>Singh, Indu</creatorcontrib><creatorcontrib>Williams, Lauren Therese</creatorcontrib><creatorcontrib>West, Nicholas P.</creatorcontrib><creatorcontrib>Colson, Natalie</creatorcontrib><title>Effect of probiotics and synbiotics on blood glucose: a systematic review and meta-analysis of controlled trials</title><title>European journal of nutrition</title><addtitle>Eur J Nutr</addtitle><addtitle>Eur J Nutr</addtitle><description>Purpose
High fasting blood glucose (FBG) can lead to chronic diseases such as diabetes mellitus, cardiovascular and kidney diseases. Consuming probiotics or synbiotics may improve FBG. A systematic review and meta-analysis of controlled trials was conducted to clarify the effect of probiotic and synbiotic consumption on FBG levels.
Methods
PubMed, Scopus, Cochrane Library, and Cumulative Index to Nursing and Allied Health Literature databases were searched for relevant studies based on eligibility criteria. Randomized or non-randomized controlled trials which investigated the efficacy of probiotics or synbiotics on the FBG of adults were included. Studies were excluded if they were review articles and study protocols, or if the supplement dosage was not clearly mentioned.
Results
A total of fourteen studies (eighteen trials) were included in the analysis. Random-effects meta-analyses were conducted for the mean difference in FBG. Overall reduction in FBG observed from consumption of probiotics and synbiotics was borderline statistically significant (−0.18 mmol/L 95 % CI −0.37, 0.00;
p
= 0.05). Neither probiotic nor synbiotic subgroup analysis revealed a significant reduction in FBG. The result of subgroup analysis for baseline FBG level ≥7 mmol/L showed a reduction in FBG of 0.68 mmol/L (−1.07, −0.29
; ρ
< 0.01), while trials with multiple species of probiotics showed a more pronounced reduction of 0.31 mmol/L (−0.58, −0.03;
ρ
=
0.03)
compared to single species trials.
Conclusion
This meta-analysis suggests that probiotic and synbiotic supplementation may be beneficial in lowering FBG in adults with high baseline FBG (≥7 mmol/L) and that multispecies probiotics may have more impact on FBG than single species.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Blood Glucose - analysis</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chronic illnesses</subject><subject>Controlled Clinical Trials as Topic</subject><subject>Diabetes mellitus</subject><subject>Evidence-based medicine</subject><subject>Fasting</subject><subject>Humans</subject><subject>Hyperglycemia</subject><subject>Hyperglycemia - prevention & control</subject><subject>MEDLINE</subject><subject>Meta-analysis</subject><subject>Middle Aged</subject><subject>Nursing</subject><subject>Nutrition</subject><subject>Original Contribution</subject><subject>Probiotics</subject><subject>Probiotics - administration & dosage</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Reviews</subject><subject>Species</subject><subject>Statistical analysis</subject><subject>Supplements</subject><subject>Synbiotics - administration & dosage</subject><subject>Systematic review</subject><issn>1436-6207</issn><issn>1436-6215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1UctKxDAUDaI44-gHuJGAGzfVPNq0dSfD-IABN7oOaR5Dh7YZc1tl_t6M8xAEVzfhPC73HIQuKbmlhOR3QAgv04RQkVBOSMKP0JimXCSC0ez48Cb5CJ0BLAkhjAt6ikYsz0qSs3KMVjPnrO6xd3gVfFX7vtaAVWcwrLv913e4arw3eNEM2oO9xyrC0NtWRRwH-1nbrx9Ra3uVqE41a6hhY6p91wffNNbgPtSqgXN04uKwF7s5Qe-Ps7fpczJ_fXqZPswTnfKiT4zLeMGUMxXhGc-VzUorXKZzo1NKRVUSyrgudEFdWghtjKty5dKMllxX3KR8gm62vvGsj8FCL9satG0a1Vk_gKRFVua04IJF6vUf6tIPIR4BksWYY8YsFZFFtywdPECwTq5C3aqwlpTITR1yW4eMdchNHZJHzdXOeahaaw6Kff6RwLYEiFC3sOF39f-u36qoljc</recordid><startdate>20180201</startdate><enddate>20180201</enddate><creator>Nikbakht, Elham</creator><creator>Khalesi, Saman</creator><creator>Singh, Indu</creator><creator>Williams, Lauren Therese</creator><creator>West, Nicholas P.</creator><creator>Colson, Natalie</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RQ</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8208-2518</orcidid></search><sort><creationdate>20180201</creationdate><title>Effect of probiotics and synbiotics on blood glucose: a systematic review and meta-analysis of controlled trials</title><author>Nikbakht, Elham ; Khalesi, Saman ; Singh, Indu ; Williams, Lauren Therese ; West, Nicholas P. ; Colson, Natalie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-df5382afdb03537ae59e6f5c7dc4116b90123c8c81f486cddfb7af45193cb3d43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Blood Glucose - analysis</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chronic illnesses</topic><topic>Controlled Clinical Trials as Topic</topic><topic>Diabetes mellitus</topic><topic>Evidence-based medicine</topic><topic>Fasting</topic><topic>Humans</topic><topic>Hyperglycemia</topic><topic>Hyperglycemia - prevention & control</topic><topic>MEDLINE</topic><topic>Meta-analysis</topic><topic>Middle Aged</topic><topic>Nursing</topic><topic>Nutrition</topic><topic>Original Contribution</topic><topic>Probiotics</topic><topic>Probiotics - administration & dosage</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Reviews</topic><topic>Species</topic><topic>Statistical analysis</topic><topic>Supplements</topic><topic>Synbiotics - administration & dosage</topic><topic>Systematic review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nikbakht, Elham</creatorcontrib><creatorcontrib>Khalesi, Saman</creatorcontrib><creatorcontrib>Singh, Indu</creatorcontrib><creatorcontrib>Williams, Lauren Therese</creatorcontrib><creatorcontrib>West, Nicholas P.</creatorcontrib><creatorcontrib>Colson, Natalie</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Career & Technical Education Database</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>ProQuest - Health & Medical Complete保健、医学与药学数据库</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Family Health Database (Proquest)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nikbakht, Elham</au><au>Khalesi, Saman</au><au>Singh, Indu</au><au>Williams, Lauren Therese</au><au>West, Nicholas P.</au><au>Colson, Natalie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of probiotics and synbiotics on blood glucose: a systematic review and meta-analysis of controlled trials</atitle><jtitle>European journal of nutrition</jtitle><stitle>Eur J Nutr</stitle><addtitle>Eur J Nutr</addtitle><date>2018-02-01</date><risdate>2018</risdate><volume>57</volume><issue>1</issue><spage>95</spage><epage>106</epage><pages>95-106</pages><issn>1436-6207</issn><eissn>1436-6215</eissn><abstract>Purpose
High fasting blood glucose (FBG) can lead to chronic diseases such as diabetes mellitus, cardiovascular and kidney diseases. Consuming probiotics or synbiotics may improve FBG. A systematic review and meta-analysis of controlled trials was conducted to clarify the effect of probiotic and synbiotic consumption on FBG levels.
Methods
PubMed, Scopus, Cochrane Library, and Cumulative Index to Nursing and Allied Health Literature databases were searched for relevant studies based on eligibility criteria. Randomized or non-randomized controlled trials which investigated the efficacy of probiotics or synbiotics on the FBG of adults were included. Studies were excluded if they were review articles and study protocols, or if the supplement dosage was not clearly mentioned.
Results
A total of fourteen studies (eighteen trials) were included in the analysis. Random-effects meta-analyses were conducted for the mean difference in FBG. Overall reduction in FBG observed from consumption of probiotics and synbiotics was borderline statistically significant (−0.18 mmol/L 95 % CI −0.37, 0.00;
p
= 0.05). Neither probiotic nor synbiotic subgroup analysis revealed a significant reduction in FBG. The result of subgroup analysis for baseline FBG level ≥7 mmol/L showed a reduction in FBG of 0.68 mmol/L (−1.07, −0.29
; ρ
< 0.01), while trials with multiple species of probiotics showed a more pronounced reduction of 0.31 mmol/L (−0.58, −0.03;
ρ
=
0.03)
compared to single species trials.
Conclusion
This meta-analysis suggests that probiotic and synbiotic supplementation may be beneficial in lowering FBG in adults with high baseline FBG (≥7 mmol/L) and that multispecies probiotics may have more impact on FBG than single species.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>27590729</pmid><doi>10.1007/s00394-016-1300-3</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-8208-2518</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1436-6207 |
| ispartof | European journal of nutrition, 2018-02, Vol.57 (1), p.95-106 |
| issn | 1436-6207 1436-6215 |
| language | eng |
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| source | Springer Nature; SPORTDiscus with Full Text |
| subjects | Adolescent Adult Aged Blood Glucose - analysis Chemistry Chemistry and Materials Science Chronic illnesses Controlled Clinical Trials as Topic Diabetes mellitus Evidence-based medicine Fasting Humans Hyperglycemia Hyperglycemia - prevention & control MEDLINE Meta-analysis Middle Aged Nursing Nutrition Original Contribution Probiotics Probiotics - administration & dosage Randomized Controlled Trials as Topic Reviews Species Statistical analysis Supplements Synbiotics - administration & dosage Systematic review |
| title | Effect of probiotics and synbiotics on blood glucose: a systematic review and meta-analysis of controlled trials |
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