A Novel Relationship for Schizophrenia, Bipolar, and Major Depressive Disorder. Part 8: a Hint from Chromosome 8 High Density Association Screen

Convergent evidence from genetics, symptomatology, and psychopharmacology implies that there are intrinsic connections between schizophrenia (SCZ), bipolar disorder (BPD), and major depressive disorder (MDD); for example, any two or even three of these disorders could co-exist in some families. A to...

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Bibliographic Details
Published in:Molecular neurobiology 2017-10, Vol.54 (8), p.5868-5882
Main Authors: Chen, Xing, Long, Feng, Cai, Bin, Chen, Xiaohong, Qin, Lizeng, Chen, Gang
Format: Article
Language:English
Subjects:
Adult
Biomedical and Life Sciences
Biomedicine
Bipolar disorder
Bipolar Disorder - genetics
Cell Biology
Chromosome 8
Chromosomes
Chromosomes, Human, Pair 8 - genetics
Cohort Studies
Density
Depressive Disorder, Major - genetics
Female
Genetic Predisposition to Disease - genetics
Genetics
Genome-Wide Association Study - methods
Genomes
Genotype
Humans
Male
Mental depression
Mental disorders
Middle Aged
Neurobiology
Neurology
Neurosciences
Polymorphism
Polymorphism, Single Nucleotide - genetics
Schizophrenia
Schizophrenia - genetics
Single-nucleotide polymorphism
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Summary:Convergent evidence from genetics, symptomatology, and psychopharmacology implies that there are intrinsic connections between schizophrenia (SCZ), bipolar disorder (BPD), and major depressive disorder (MDD); for example, any two or even three of these disorders could co-exist in some families. A total of 48,753 single nucleotide polymorphisms (SNPs) on chromosome 8 were genotyped by Affymetrix Genome-Wide Human SNP array 6.0 on 119 SCZ, 253 BPD (type I), 177 MDD patients, and 1000 controls. Associated SNP loci were comprehensively revealed, and outstanding susceptibility genes were identified including CSMD1 , NRG1 , PXDNL , SGCZ , and TMEM66. Unexpectedly, flanking genes for up to 95.9 % of the associated SNPs were replicated ( P  ≤ 9.9E−8) in the enlarged cohort of 986 SCZ patients. Considering convergent evidence, our results implicate that bipolar disorder and major depressive disorder might be subtypes of schizophrenia.
ISSN:0893-7648
1559-1182
DOI:10.1007/s12035-016-0102-1