Lipid ratio as a suitable tool to identify individuals with MetS risk: A case- control study

Abstract Aims This study aimed to compare the serum lipids ratio in staff with and without metabolic syndrome (MetS) who were working in Shahroud University of Medical Sciences. Methods This case-control study was conducted in 2015 on 499 personnel aged 30–60 years old. ATP III criteria were used to...

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Bibliographic Details
Published in:Diabetes & metabolic syndrome clinical research & reviews 2017-11, Vol.11, p.S15-S19
Main Authors: Abbasian, Maryam, M.Sc in Biochemistry, Delvarianzadeh, Mehri, M.Sc in Nutrition, Ebrahimi, Hossein, PhD in Nursing, Khosravi, Farideh, M.Sc in Biostatistics
Format: Article
Language:English
Subjects:
Adult
Biomarkers - blood
Case-Control Studies
Cholesterol, HDL - blood
Endocrinology & Metabolism
Female
Follow-Up Studies
Humans
LDL-C/HDL-C
Lipid ratios
Lipids - blood
Male
Metabolic syndrome
Metabolic Syndrome - blood
Metabolic Syndrome - diagnosis
Metabolic Syndrome - etiology
Middle Aged
NonHDL-C/HDL-C
Prognosis
Risk Factors
ROC Curve
TC/HDL-C
TG/HDL
Triglycerides - blood
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Summary:Abstract Aims This study aimed to compare the serum lipids ratio in staff with and without metabolic syndrome (MetS) who were working in Shahroud University of Medical Sciences. Methods This case-control study was conducted in 2015 on 499 personnel aged 30–60 years old. ATP III criteria were used to diagnose patients with MetS. The data were analyzed by using logistic regression and ROC curve. Results Mean lipid ratio was higher in individuals having the MetS in both sexes compared with those without. In addition, the mean levels of lipid ratios significantly increased with increasing number of MetS components in both sexes. Also it could be concluded that TG/HDL-C ratio is the best marker for the diagnosis of MetS in men and women. Moreover, the cut-off point for the TG/HDL-C was 2.86 in women and 4.03 in men. It was found that for any unit of increases in the TG/HDL-C, the risk of developing the MetS will increase by 2.12 times. Conclusions TG/HDL-C ratio is found to be the best clinical marker for the diagnosis of MetS compare with other lipid ratios, therefore it is recommended to be used as a feasible tool to identify individuals with MetS risk.
ISSN:1871-4021
1878-0334
DOI:10.1016/j.dsx.2016.08.011