Niacinamide leave‐on formulation provides long‐lasting protection against bacteria in vivo

Antimicrobial peptides (AMPs) form a part of the skin's innate immune system. Their primary activity is to provide antimicrobial benefits and hence protect from infections. AMPs that are present on human skin include psoriasin (S100A7), RNase 7, lysozyme, LL‐37 and defensins. Niacinamide is a w...

Full description

Saved in:
Bibliographic Details
Published in:Experimental dermatology 2017-09, Vol.26 (9), p.827-829
Main Authors: Mathapathi, Mruthyunjaya Swamy, Mallemalla, Prathyusha, Vora, Shilpa, Iyer, Vidula, Tiwari, Jyoti Kumar, Chakrabortty, Amit, Majumdar, Amitabha
Format: Article
Language:English
Subjects:
Adult
antimicrobial peptide
Antimicrobial peptides
Bacteria
Defensins
Epithelial cells
Escherichia coli - drug effects
Healthy Volunteers
Humans
Immune system
Innate immunity
Leukocytes (neutrophilic)
Lysozyme
niacinamide
Niacinamide - pharmacology
Nicotinamide
psoriasin
Ribonuclease 7
Skin
Skin - drug effects
Skin - microbiology
skin immunity
Staphylococcus aureus - drug effects
Vitamin B Complex - pharmacology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Antimicrobial peptides (AMPs) form a part of the skin's innate immune system. Their primary activity is to provide antimicrobial benefits and hence protect from infections. AMPs that are present on human skin include psoriasin (S100A7), RNase 7, lysozyme, LL‐37 and defensins. Niacinamide is a well‐known cosmetic ingredient that has been used traditionally for multiple skin benefits. Recent data indicate that niacinamide treatment can boost AMPs in human gut epithelial cells and in neutrophils. Treatment with niacinamide in mice also provided protection from skin infections by enhancing AMPs. In this article, we find that treatment with niacinamide formulation provides long‐lasting protection against bacteria, potentially through the activation of an AMP response.
ISSN:0906-6705
1600-0625
DOI:10.1111/exd.13285