Anesthetic considerations for patients with esophageal achalasia undergoing peroral endoscopic myotomy: a retrospective case series review

• Published in: Canadian journal of anesthesia 2017-05, Vol.64 (5), p.480-488
• Main Authors: Löser, Benjamin, Werner, Yuki B., Punke, Mark A., Saugel, Bernd, Haas, Sebastian, Reuter, Daniel A., Mann, Oliver, Duprée, Anna, Schachschal, Guido, Rösch, Thomas, Petzoldt, Martin
• Format: Article
• Language: English
• Subjects: Abdomen; Adult; Anesthesia Recovery Period; Anesthesiology; Anesthetics - administration & dosage; Arterial Pressure - physiology; Carbon dioxide; Carbon Dioxide - administration & dosage; Cardiology; Critical Care Medicine; Dissection; Emphysema; Endoscopy; Esophageal Achalasia - pathology; Esophageal Achalasia - surgery; Esophagoscopy - methods; Esophagus; Extubation; Female; Heart Rate - physiology; Humans; Hyperventilation; Intensive; Male; Medicine; Medicine & Public Health; Middle Aged; Pain Medicine; Pediatrics; Pneumology/Respiratory System; Pneumoperitoneum - etiology; Pneumothorax; Postoperative Complications - epidemiology; Pressure; Reports of Original Investigations; Retrospective Studies; Subcutaneous Emphysema - epidemiology; Subcutaneous Emphysema - etiology; Thoracic surgery; Ventilators
• ISSN: 0832-610X; 1496-8975
• DOI: 10.1007/s12630-017-0820-5

Purpose Peroral endoscopic myotomy (POEM) is a novel technique for treating esophageal achalasia. During POEM, carbon dioxide (CO 2 ) is insufflated to aid surgical dissection, but it may inadvertently track into surrounding tissues, causing systemic CO 2 uptake and tension capnoperitoneum. This in turn may affect cardiorespiratory function. This study quantified these cardiorespiratory effects and treatment by hyperventilation and percutaneous abdominal needle decompression (PND). Methods One hundred and seventy-three consecutive patients who underwent POEM were included in this four-year retrospective study. Procedure-related changes in peak inspiratory pressure (p max ), end-tidal CO 2 levels (etCO 2 ), minute ventilation (MV), mean arterial pressure (MAP), and heart rate (HR) were analyzed. We also quantified the impact of PND on these cardiorespiratory parameters. Results During the endoscopic procedure, cardiorespiratory parameters increased from baseline: p max 15.1 (4.5) vs 19.8 (4.7) cm H 2 O; etCO 2 4.5 (0.4) vs 5.5 (0.9) kPa [34.0 (2.9) vs 41.6 (6.9) mmHg]; MAP 73.9 (9.7) vs 99.3 (15.2) mmHg; HR 67.6 (12.4) vs 85.3 (16.4) min −1 ( P < 0.001 for each). Hyperventilation [MV 5.9 (1.2) vs 9.0 (1.8) L·min −1 , P < 0.001] was applied to counteract iatrogenic hypercapnia. Individuals with tension capnoperitoneum treated with PND ( n = 55) had higher peak p max values [22.8 (5.7) vs 18.4 (3.3) cm H 2 O, P < 0.001] than patients who did not require PND. After PND, p max [22.8 (5.7) vs 19.9 (4.3) cm H 2 O, P = 0.045] and MAP [98.2 (16.3) vs 88.6 (11.8) mmHg, P = 0.013] decreased. Adverse events included pneumothorax ( n = 1), transient myocardial ischemia ( n = 1), and subcutaneous emphysema ( n = 49). The latter precluded immediate extubation in eight cases. Postanesthesia care unit (PACU) stay was longer in individuals with subcutaneous emphysema than in those without [74.9 min (34.5) vs 61.5 (26.8 min), P = 0.007]. Conclusion Carbon dioxide insufflation during POEM produces systemic CO 2 uptake and increased intra-abdominal pressure. Changes in cardiorespiratory parameters include increased p max , etCO 2 , MAP, and HR. Hyperventilation and PND help mitigate some of these changes. Subcutaneous emphysema is common and may delay extubation and prolong PACU stay.