Dysmorphism in non-syndromic autism: A cross-sectional study

Objectives To determine the effect of association of dysembryogenesis (manifested by presence of dysmorphic markers) on the developmental profile of autistic children. Methods 26 autistic children were classified into complex autism (if they had specific dysmorphic markers) or essential autism (in t...

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Bibliographic Details
Published in:Indian pediatrics 2017-07, Vol.54 (7), p.560-562
Main Authors: Zachariah, Susan Mary, Oommen, Samuel Philip, Padankatti, Caroline Sanjeev, Grace, Hannah, Glory, Lincy
Format: Article
Language:English
Subjects:
Autistic Disorder - classification
Autistic Disorder - epidemiology
Child
Child, Preschool
Cross-Sectional Studies
Developmental Disabilities
Female
Humans
Male
Maternal and Child Health
Medicine
Medicine & Public Health
Pediatric Surgery
Pediatrics
Prevalence
Research Paper
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Summary:Objectives To determine the effect of association of dysembryogenesis (manifested by presence of dysmorphic markers) on the developmental profile of autistic children. Methods 26 autistic children were classified into complex autism (if they had specific dysmorphic markers) or essential autism (in the absence of dysmorphic markers) using the Miles Autism Dysmorphology Measure (ADM). The developmental abilities (Griffith’s Mental Development Scales) and the clinical severity (Childhood Autism Rating Scale) of both groups were compared. The prevalence of dysmorphic markers was also determined in 140 non-autistic controls. Results Children with complex autism had poorer development (General Quotient 29.4 vs 34.0, P =0.06) and earlier onset of autistic symptoms (18 vs 24 mo, P =0.05). Dysmorphic markers were significantly more in autistic children compared to normal children (27% vs 10%, P =0.002). Conclusions Dysembryogenesis may contribute to the clinical heterogeneity of autistic children.
ISSN:0019-6061
0974-7559
DOI:10.1007/s13312-017-1068-4