Inner Hair Cell Loss Disrupts Hearing and Cochlear Function Leading to Sensory Deprivation and Enhanced Central Auditory Gain

There are three times as many outer hair cells (OHC) as inner hair cells (IHC), yet IHC transmit virtually all acoustic information to the brain as they synapse with 90-95% of type I auditory nerve fibers. Here we review a comprehensive series of experiments aimed at determining how loss of the IHC/...

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Bibliographic Details
Published in:Frontiers in neuroscience 2017-01, Vol.10, p.621
Main Authors: Salvi, Richard, Sun, Wei, Ding, Dalian, Chen, Guang-Di, Lobarinas, Edward, Wang, Jian, Radziwon, Kelly, Auerbach, Benjamin D.
Format: Article
Language:English
Subjects:
Action potential
Auditory nerve
Auditory system
Carboplatin
Cochlea
Cortex (auditory)
Drug dosages
Ears & hearing
Fibers
Hair cells
Hearing
Hearing loss
Hearing protection
Inferior colliculus
Information processing
Neurons
Neuroscience
Ototoxicity
Outer hair cells
Sensory deprivation
Somatosensory cortex
Tinnitus
γ-Aminobutyric acid
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