Surgical Resection for Lymph Node Metastasis After Liver Transplantation for Hepatocellular Carcinoma

Treatment strategies for lymph node (LN) metastasis after liver transplantation (LT) for hepatocellular carcinoma (HCC) have not been studied. The treatment modes and outcomes in patients with LN metastasis after LT (n=6) for HCC were reviewed. The mean time from LT to LN recurrence was 2.0±1.3 year...

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Bibliographic Details
Published in:Anticancer research 2017-02, Vol.37 (2), p.891-896
Main Authors: Ikegami, Toru, Yoshizumi, Tomoharu, Kawasaki, Jyunji, Nagatsu, Akihisa, Uchiyama, Hideaki, Harada, Noboru, Harimoto, Norifumi, Itoh, Shinji, Motomura, Takashi, Soejima, Yuji, Maehara, Yoshihiko
Format: Article
Language:English
Subjects:
Adult
Aged
Antineoplastic Agents - therapeutic use
Carcinoma, Hepatocellular - pathology
Carcinoma, Hepatocellular - surgery
Carcinoma, Hepatocellular - therapy
Chemoradiotherapy - methods
Feasibility Studies
Female
Humans
Liver - drug effects
Liver - radiation effects
Liver - surgery
Liver Neoplasms - pathology
Liver Neoplasms - surgery
Liver Neoplasms - therapy
Liver Transplantation - methods
Lymphatic Metastasis
Male
Middle Aged
Neoplasm Recurrence, Local
Niacinamide - analogs & derivatives
Niacinamide - therapeutic use
Phenylurea Compounds - therapeutic use
Survival Analysis
Time Factors
Treatment Outcome
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Summary:Treatment strategies for lymph node (LN) metastasis after liver transplantation (LT) for hepatocellular carcinoma (HCC) have not been studied. The treatment modes and outcomes in patients with LN metastasis after LT (n=6) for HCC were reviewed. The mean time from LT to LN recurrence was 2.0±1.3 years, and the locations of the LNs recurrences included the phrenic (n=2), common hepatic artery (n=2), inferior vena cava (n=1) and gastric (n=1) regions. Treatments included surgery alone (n=3), surgery followed by chemoradiation (n=1), radiation followed by chemotherapy (n=1), and chemotherapy, radiation and sorafenib (n=1). Although the patients receiving non-surgical treatments (n=3) died within 1.2 years, those who underwent surgical removal of the metastatic LNs survived 11.2 years, 4.5 years and 0.8 years, respectively, without any signs of re-recurrence. Surgical resection is the only feasible and potentially curative treatment for LN metastasis after LT for HCC.
ISSN:0250-7005
1791-7530
DOI:10.21873/anticanres.11395