Advantage of high b value diffusion-weighted imaging for differentiation of hemangioblastoma from brain metastases in posterior fossa

Abstract Objective It is sometimes difficult to make differential diagnosis between brain metastases and hemangioblastoma in posterior fossa. We assessed whether high b-value diffusion weighted image (DWI) at b-4000 could differentiate these tumors. Methods We acquired DWI at 3T magnetic resonance i...

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Bibliographic Details
Published in:World neurosurgery 2017-05, Vol.101, p.643-650
Main Authors: Onishi, Shumpei, Hirose, Takanori, Takayasu, Takeshi, Nosaka, Ryo, Kolakshyapati, Manish, Saito, Taiichi, Akiyama, Yuji, Sugiyama, Kazuhiko, Kurisu, Kaoru, Yamasaki, Fumiyuki
Format: Article
Language:English
Subjects:
Adult
Aged
Apparent diffusion coefficient
Brain metastases
Brain Neoplasms - diagnostic imaging
Brain Neoplasms - surgery
Cerebellar Neoplasms - diagnostic imaging
Cerebellar Neoplasms - surgery
Diagnosis, Differential
Diffusion Magnetic Resonance Imaging - methods
Diffusion Magnetic Resonance Imaging - standards
Diffusion-weighted image
Female
Hemangioblastoma
Hemangioblastoma - diagnostic imaging
Hemangioblastoma - surgery
High b value
Humans
Infratentorial Neoplasms - diagnostic imaging
Infratentorial Neoplasms - surgery
Male
Middle Aged
Neurosurgery
Retrospective Studies
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Summary:Abstract Objective It is sometimes difficult to make differential diagnosis between brain metastases and hemangioblastoma in posterior fossa. We assessed whether high b-value diffusion weighted image (DWI) at b-4000 could differentiate these tumors. Methods We acquired DWI at 3T magnetic resonance imaging (MRI) with b = 1000 and b = 4000 s/mm2 in histologically confirmed 12 patients of hemangioblastoma without von-Hippel Lindau disease and 16 patients of brain metastases originating at posterior fossa. Apparent diffusion coefficient (ADC) values were measured by manually placing regions of interest (ROIs) on ADC maps at the site of enhanced tumor confirmed on contrast-enhanced T1- weighed image. ADC was expressed as the minimum (ADCMIN ), mean (ADCMEAN ), and maximum (ADCMAX ) values. Results All the ADC values of hemangioblastoma were statistically higher than that of metastatic tumor in both b-1000 and b-4000 (p
ISSN:1878-8750
1878-8769
DOI:10.1016/j.wneu.2017.01.100