Plasma levels of miR-137 and miR-124 are associated with Parkinson’s disease but not with Parkinson’s disease with depression

MicroRNAs (miRNAs) are a class of small, non-coding RNAs that regulate gene expression at the post-transcriptional level. Recently, it was reported that miR-137, miR-124, and miR-184 were widely expressed in the central nervous system and were vital to neuronal regulation. In this study, we detected...

Full description

Saved in:
Bibliographic Details
Published in:Neurological sciences 2017-05, Vol.38 (5), p.761-767
Main Authors: Li, Na, Pan, Xudong, Zhang, Jingli, Ma, Aijun, Yang, Shaonan, Ma, Juanjuan, Xie, Anmu
Format: Article
Language:English
Subjects:
Aged
Biomarkers
Central nervous system
Correlation analysis
Depression - blood
Depression - complications
Female
Gene expression
Humans
Male
Medicine
Medicine & Public Health
Mental depression
MicroRNAs - blood
MicroRNAs - genetics
Middle Aged
miRNA
Motor task performance
Movement disorders
Neurodegenerative diseases
Neurology
Neuroradiology
Neurosciences
Neurosurgery
Non-coding RNA
Original Article
Parkinson Disease - blood
Parkinson Disease - complications
Parkinson's disease
Plasma
Plasma levels
Polymerase chain reaction
Post-transcription
Psychiatric Status Rating Scales
Psychiatry
Retrospective Studies
RNA, Messenger - metabolism
ROC Curve
Transcription
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:MicroRNAs (miRNAs) are a class of small, non-coding RNAs that regulate gene expression at the post-transcriptional level. Recently, it was reported that miR-137, miR-124, and miR-184 were widely expressed in the central nervous system and were vital to neuronal regulation. In this study, we detected the circulating levels of miR-137, miR-124, and miR-184 in PD patients, and explored the potential role of miR-124, miR-137, and miR-184 in the diagnosis of PD. We further described the relationship between these miRNAs and PD with depression (PD-Dep). The study recruited 60 controls and 60 PD patients, which were further divided into two subgroups, PD with depression (PD-Dep, n  = 24) and non-depressed group (PD-NDep, n  = 36) according to Hamilton Rating Scale for Depression. Plasma levels of miR-137, miR-124, and miR-184 were detected by qRT-PCR. Receiver-operating characteristic (ROC) curve was used to evaluate miR-124 and miR-137 levels as potential diagnostic biomarkers for PD. The results demonstrated that there were no significant differences in levels of miR-184 between PD patients and controls ( p  > 0.05). However, miR-137 levels were increased significantly for PD patients compared to controls ( p  
ISSN:1590-1874
1590-3478
DOI:10.1007/s10072-017-2841-9