Is celecoxib a useful adjunct in the treatment of post-tonsillectomy pain in the adult population? A randomised, double-blind, placebo-controlled study

To evaluate the efficacy and safety of celecoxib for pain management in post-tonsillectomy adult patients. A randomised, double-blind, placebo-controlled, phase 3 clinical trial was conducted in an adult population (aged 18-55 years), with a parallel group design using an allocation ratio of 1:1. Ei...

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Bibliographic Details
Published in:Journal of laryngology and otology 2017-01, Vol.131 (S1), p.S18-S28
Main Authors: Ng, T-T, Diamantaras, D, Priestley, J, Redman, J, De Silva, N, Mahanta, V
Format: Article
Language:English
Subjects:
Acetaminophen - therapeutic use
Adolescent
Adult
Analgesics
Analgesics - therapeutic use
Celecoxib - therapeutic use
Cyclooxygenase 2 Inhibitors - therapeutic use
Double-Blind Method
Drug Therapy, Combination
Female
Hemorrhage
Hospitals
Humans
Inflammation
Main Articles
Male
Middle Aged
Narcotics
Oxycodone - therapeutic use
Pain
Pain, Postoperative - drug therapy
Patients
Postoperative Nausea and Vomiting - epidemiology
Surgeons
Tonsillectomy
Young Adult
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Summary:To evaluate the efficacy and safety of celecoxib for pain management in post-tonsillectomy adult patients. A randomised, double-blind, placebo-controlled, phase 3 clinical trial was conducted in an adult population (aged 18-55 years), with a parallel group design using an allocation ratio of 1:1. Eighty patients underwent elective tonsillectomy or adenotonsillectomy, operated on by one surgeon. They were discharged home with randomly assigned celecoxib or placebo, together with regular post-tonsillectomy medications (paracetamol and Endone). Pain scores were measured from post-operative days 1 to 10. All patients were assessed on post-operative days 5, 12 and 28. There were no statistically significant differences in the daily or overall pain scores, the total intake of Endone, or the time taken to achieve freedom from pain after tonsillectomy between the study arms (n = 40 each arm). The celecoxib-treated group experienced significantly more vomiting (celecoxib vs placebo p < 0.001 (Mann-Whitney test), confidence interval = 0.57 to 0.76). Celecoxib usage was associated with significantly more vomiting and did not reduce narcotic analgesia requirement post-tonsillectomy.
ISSN:0022-2151
1748-5460
DOI:10.1017/S0022215116009476