Successful osteoconduction but limited cartilage tissue quality following osteochondral repair by a cell-free multilayered nano-composite scaffold at the knee

Introduction The treatment of larger osteochondral lesions in the knee is still a clinical challenge. One promising strategy to overcome this problem could be surgical repair by using a cell-free multilayered nano-composite scaffold. Method In this prospective cohort study eight consecutive patients...

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Bibliographic Details
Published in:International orthopaedics 2016-03, Vol.40 (3), p.625-632
Main Authors: Brix, Martin, Kaipel, Martin, Kellner, Richard, Schreiner, Markus, Apprich, Sebastian, Boszotta, Harald, Windhager, Reinhard, Domayer, Stephan, Trattnig, Siegfried
Format: Article
Language:English
Subjects:
Adolescent
Adult
Bone Regeneration
Cartilage Diseases - pathology
Cartilage Diseases - surgery
Cartilage, Articular - pathology
Cohort Studies
Female
Femur - pathology
Follow-Up Studies
Humans
Knee Joint - surgery
Magnetic Resonance Imaging
Male
Medicine
Medicine & Public Health
Middle Aged
Nanocomposites - therapeutic use
Original Paper
Orthopedics
Prospective Studies
Tissue Scaffolds
Treatment Outcome
Wound Healing
Young Adult
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Summary:Introduction The treatment of larger osteochondral lesions in the knee is still a clinical challenge. One promising strategy to overcome this problem could be surgical repair by using a cell-free multilayered nano-composite scaffold. Method In this prospective cohort study eight consecutive patients which suffered from a single osteochondral lesion (≥1.5 cm 2 ) on the femoral condyle were enrolled. The repair potential of the implant was assessed by using MRI based biochemical MR sequences (T2 mapping) as well as semi-quantitative morphological analyses (MOCART score) at 18 months after the surgery. The clinical outcome was determined at six, 12, 18, and 24 month follow ups by using IKDC, Tegner-Lysholm, and Cincinnati knee scores. Results Seven out of eight patients showed a complete integration of the scaffold into the border zone and five out of eight patients excellent or good subchondral ossification of the implant at 18 months following implantation. The surface of the repair tissue was found to be intact in all eight patients. T2 mapping data and the zonal T2 index significantly differed in the repair tissue compared to the healthy control cartilage ( P  
ISSN:0341-2695
1432-5195
DOI:10.1007/s00264-016-3118-2