Coronary flow reserve in patients with resistant hypertension

Resistant hypertension is associated with increased risk for cardiovascular events. Coronary flow reserve (CFR) is impaired in patients with hypertension and an independent predictor of cardiac mortality. However, there are no published data on CFR in the subset of treatment-resistant hypertension....

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Bibliographic Details
Published in:Clinical research in cardiology 2017-02, Vol.106 (2), p.151-157
Main Authors: Völz, Sebastian, Svedlund, Sara, Andersson, Bert, Li-Ming, Gan, Rundqvist, Bengt
Format: Article
Language:English
Subjects:
Adenosine - administration & dosage
Aged
Antihypertensive Agents - therapeutic use
Blood Flow Velocity
Blood Pressure - drug effects
Cardiology
Case-Control Studies
Coronary Circulation
Coronary Vessels - diagnostic imaging
Coronary Vessels - physiopathology
Drug Resistance
Echocardiography, Doppler, Color
Female
Heart Diseases - diagnostic imaging
Heart Diseases - etiology
Heart Diseases - physiopathology
Humans
Hypertension - complications
Hypertension - diagnosis
Hypertension - physiopathology
Male
Medicine
Medicine & Public Health
Microcirculation
Middle Aged
Original Paper
Predictive Value of Tests
Prognosis
Risk Factors
Vasodilator Agents - administration & dosage
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Summary:Resistant hypertension is associated with increased risk for cardiovascular events. Coronary flow reserve (CFR) is impaired in patients with hypertension and an independent predictor of cardiac mortality. However, there are no published data on CFR in the subset of treatment-resistant hypertension. The aim of this study was to assess CFR in patients with resistant hypertension. Twenty-five consecutive patients with primary resistant hypertension, scheduled for renal denervation, 25 matched patients with controlled hypertension, and 25 healthy controls underwent transthoracic colour Doppler echocardiography at rest and during adenosine infusion. Patients with hypertension were pair-matched with regard to age, sex, ischemic heart disease, diabetes mellitus, smoking status, and body-mass index. Healthy controls were selected according to age and sex. Mean flow velocity was measured in the left coronary anterior descending artery. Baseline mean flow velocities were similar in patients with controlled and resistant hypertension. CFR was significantly lower in patients with resistant hypertension as compared to individuals with non-resistant hypertension (2.7 ± 0.6 vs. 3.1 ± 0.8; p  = 0.03). Systolic office blood pressure was significantly higher in patients with resistant hypertension (169 ± 20 vs. 144 ± 21 mm Hg; p  
ISSN:1861-0684
1861-0692
DOI:10.1007/s00392-016-1043-4