Histomorphometric characterization of subgemmal neurogenous plaques

Abstract Objectives Characterize the histomorphometric features of subgemmal neurogenous plaques (SNPs) to better understand their relationship to surrounding microanatomy included in within the tissue biopsy samples of the tongue. Study design A 12-year retrospective study on the files of 3 oral pa...

Full description

Saved in:
Bibliographic Details
Published in:Oral surgery, oral medicine, oral pathology and oral radiology oral medicine, oral pathology and oral radiology, 2017-04, Vol.123 (4), p.477-481
Main Authors: Pellicioli, Ana Carolina Amorim, DDS, PhD student, Fonseca, Felipe Paiva, DDS, PhD, Silva, Rodrigo Neves, DDS, PhD student, Gueiros, Luiz Alcino Monteiro, DDS, PhD, de Almeida, Oslei Paes, DDS, PhD, Vargas, Pablo Agustin, DDS, PhD, Lopes, Marcio Ajudarte, DDS, PhD, Pontes, Helder Antonio Rebelo, DDS, PhD, Martins, Manoela Domingues, DDS, PhD, Carrard, Vinícius Coelho, DDS, PhD, dos Santos Silva, Alan Roger, DDS, PhD
Format: Article
Language:English
Subjects:
Dentistry
Diagnosis, Differential
Female
Humans
Immunohistochemistry
Male
Middle Aged
Retrospective Studies
Surgery
Taste Buds - anatomy & histology
Tongue - anatomy & histology
Tongue - innervation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Objectives Characterize the histomorphometric features of subgemmal neurogenous plaques (SNPs) to better understand their relationship to surrounding microanatomy included in within the tissue biopsy samples of the tongue. Study design A 12-year retrospective study on the files of 3 oral pathology centers retrieved 28 cases of SNPs. Hematoxylin and eosin stained sections were used to histological analysis, whereas immunohistochemical staining for S100 protein was performed to better characterize the neural structures. Slides were scanned and histomorphometric analysis carried out using ImageScope software. Results Twenty-one women (75%) and seven (21.4%) men comprised the sample with a mean age of 46.4 and 49 years, respectively. According to the morphological characterization, 20 (71,4%) cases were juxtaposed to the tongue epithelium and 16 (57,1%) cases were associated with lymphoid tissue. The mean area of the SNPs was 0.160 mm2 and the mean distance to the overlying epithelium was 0.311 mm. Conclusion SNPs are normal neural structures located on the posterior border of the tongue that represent a non-neoplastic regional anatomical variation. In some cases, signs or symptoms might be present and further investigation should be performed. Pathologists should be aware of this entity to avoid misdiagnosis with neural lesions.
ISSN:2212-4403
2212-4411
DOI:10.1016/j.oooo.2016.12.014