Evaluation of renal function in a specific population of living kidney donors

• Published in: Journal of renal care 2017-06, Vol.43 (2), p.114-120
• Main Authors: de Souza Rodrigues, Thalyta, Amorim de Albuquerque, Ana Letícia, de Oliveira Cosme, Fillipe Agra, de Oliveira, José Ayrton Macedo Guimarães, Magalhães, Indalécio, Teles, Flávio, Pedrosa, André Falcão
• Format: Article
• Language: English
• Subjects: Adult; Aged; Albuminuria - urine; Blood & organ donations; Blood Pressure; Body Mass Index; Brazil; Chronic kidney disease; Creatinine - analysis; Creatinine - blood; Cross-Sectional Studies; Female; Glomerular Filtration Rate; Humans; Kidney - physiology; Kidney transplantation; Kidney Transplantation - adverse effects; Kidney Transplantation - methods; Kidneys; Living donors; Living Donors - statistics & numerical data; Long Term Adverse Effects; Male; Middle Aged; Nephrectomy - rehabilitation; Nephrectomy - standards; Nursing; Quantitative analysis; Tissue and Organ Harvesting - adverse effects; Transplants & implants
• ISSN: 1755-6678; 1755-6686
• DOI: 10.1111/jorc.12198

SUMMARY Background The increase in candidates for kidney transplant has led to growth in the number of living donor transplants. Therefore, studies that adequately evaluate the possible long‐term consequences of elective transplant nephrectomy are needed. Objective To evaluate the possible long‐term adverse effects of transplant nephrectomy on the renal function of living kidney donors. Design A cross‐sectional study. Participants Thirty‐three living kidney donors registered in the transplant programme of a centre in Alagoas, Brazil. Measurements Demographic characteristics, anthropometric measures, clinical data and biomarkers (creatinine, eGFR, microalbuminuria, cholesterol and triglycerides) were measured. Creatinine clearance was calculated using the Cockcroft‐Gault and Modification of Diet in Renal Disease formulae. Results Of the 33 individuals, 63.63% were female, and the median age was 45 years. Additionally, 24.24% of these individuals had altered blood pressure, 39.39% had altered abdominal circumference (AC) and 36.36% were obese, with a body mass index ≥30. Furthermore, 33.33% of these individuals had elevated triglyceride levels. The average eGFR was 97.33 (33.03–175.9) ml/min/1.73 m2 (CG) and 84.14 (29.4–131) ml/min/1.73 m2 (MDRD). The microalbuminuria level was altered in 12.12% patients. Conclusion Kidney donation is unquestionably a safe procedure. However, a better understanding of the long‐term consequences of living donor kidney transplantation is still needed. This knowledge may have important implications for the follow‐up of these patients. Our study has demonstrated a non‐negligible presence of an early marker of glomerular injury and a decrease in the GFR of some patients, thereby reinforcing the proposal for long‐term follow‐up of living kidney donors.