Pulmonary adenocarcinoma with epidermal growth factor receptor‐mutations in asbestos exposed non‐smokers: A case series

Background Cigarette smoke and asbestos are recognized causes of lung carcinoma and together promote carcinogenesis. Adenocarcinoma is currently the most common cause of lung cancer in the USA and it has been linked to both smoking and asbestos exposure. Mutations in the epidermal growth factor gene...

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Bibliographic Details
Published in:American journal of industrial medicine 2017-03, Vol.60 (3), p.306-309
Main Authors: Kradin, Richard L., Iafrate, John, Christiani, David C.
Format: Article
Language:English
Subjects:
adenocarcinoma
Adenocarcinoma - etiology
Adenocarcinoma - genetics
Adenocarcinoma of Lung
Aged
asbestos
Asbestos - toxicity
cigarette smoke
epidermal growth factor receptor
ErbB Receptors - genetics
Humans
Lung Neoplasms - etiology
Lung Neoplasms - genetics
Male
Middle Aged
Mutation
Occupational Diseases - etiology
Occupational Diseases - genetics
Occupational Exposure - adverse effects
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Summary:Background Cigarette smoke and asbestos are recognized causes of lung carcinoma and together promote carcinogenesis. Adenocarcinoma is currently the most common cause of lung cancer in the USA and it has been linked to both smoking and asbestos exposure. Mutations in the epidermal growth factor gene receptor (EGFR) occur predominantly in non‐smokers with adenocarcinoma. Methods Mutations in the EGFR gene were investigated using next‐generation sequencing. Results We report the presence of EGFR exon point mutations in the pulmonary adenocarcinomas of three never‐smokers occupationally exposed to asbestos. Conclusion The role of asbestos as a possible cause of EGFR mutagenesis requires further investigation. Am. J. Ind. Med. 60:306–309, 2017. © 2017 Wiley Periodicals, Inc.
ISSN:0271-3586
1097-0274
DOI:10.1002/ajim.22691