Impact of pre-admission depression on mortality following myocardial infarction

The prognostic impact of previous depression on myocardial infarction survival remains poorly understood. To examine the association between depression and all-cause mortality following myocardial infarction. Using Danish medical registries, we conducted a nationwide population-based cohort study. W...

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Bibliographic Details
Published in:British journal of psychiatry 2017-05, Vol.210 (5), p.356-361
Main Authors: Sundbøll, Jens, Schmidt, Morten, Adelborg, Kasper, Pedersen, Lars, Bøtker, Hans Erik, Videbech, Poul, Sørensen, Henrik Toft
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Antidepressants
Cardiovascular disease
Cohort analysis
Denmark - epidemiology
Depressive Disorder - complications
Depressive Disorder - mortality
Diagnosis
Female
Health risk assessment
Humans
Kaplan-Meier Estimate
Male
Medical diagnosis
Mental depression
Middle Aged
Mortality
Mortality rates
Myocardial infarction
Myocardial Infarction - mortality
Myocardial Infarction - psychology
Population studies
Prognosis
Prospective Studies
Psychiatry
Risk Factors
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Summary:The prognostic impact of previous depression on myocardial infarction survival remains poorly understood. To examine the association between depression and all-cause mortality following myocardial infarction. Using Danish medical registries, we conducted a nationwide population-based cohort study. We included all patients with first-time myocardial infarction (1995-2014) and identified previous depression as either a depression diagnosis or use of antidepressants. We used Cox regression to compute adjusted mortality rate ratios (aMRRs) with 95% confidence intervals. We identified 170 771 patients with first-time myocardial infarction. Patients with myocardial infarction and a previous depression diagnosis had higher 19-year mortality risks (87% 78%). The overall aMRR was 1.11 (95% CI 1.07-1.15) increasing to 1.22 (95% CI 1.17-1.27) when including use of antidepressants in the depression definition. A history of depression was associated with a moderately increased all-cause mortality following myocardial infarction.
ISSN:0007-1250
1472-1465
DOI:10.1192/bjp.bp.116.194605