Integrated multi-omic analyses in Biomphalaria-Schistosoma dialogue reveal the immunobiological significance of FREP-SmPoMuc interaction

• Published in: Developmental and comparative immunology 2017-10, Vol.75, p.16-27
• Main Authors: Portet, Anaïs, Pinaud, Silvain, Tetreau, Guillaume, Galinier, Richard, Cosseau, Céline, Duval, David, Grunau, Christoph, Mitta, Guillaume, Gourbal, Benjamin
• Format: Article
• Language: English
• Subjects: Animals; Antigens; Antigens, Helminth - genetics; Antigens, Helminth - metabolism; Biological Evolution; Biomphalaria - immunology; Biomphalaria - parasitology; Biomphalaria glabrata; Compatibility; Compatibility polymorphism; Disease Vectors; Fibrinogen; FREPs; Fresh water; Freshwater environments; Host-Parasite Interactions; Human behavior; Humans; Immunoglobulins - genetics; Immunoglobulins - metabolism; Infectivity; Large scale integration; Molecules; Mollusks; Mucins; Mucins - genetics; Mucins - metabolism; Polymorphism; Polymorphism, Genetic; Proteins; Proteomics; Receptors; Schistosoma mansoni; Schistosoma mansoni - immunology; Schistosomiasis; Schistosomiasis - immunology; SmPoMucs; Transcriptome; Vectors
• ISSN: 0145-305X; 1879-0089
• DOI: 10.1016/j.dci.2017.02.025

The fresh water snail Biomphalaria glabrata is one of the vectors of the trematode pathogen Schistosoma mansoni, which is one of the agents responsible of human schistosomiasis. In this host–parasite interaction, co-evolutionary dynamic results into an infectivity mosaic known as compatibility polymorphism. Integrative approaches including large scale molecular approaches have been conducted in recent years to improve our understanding of the mechanisms underlying compatibility. This review presents the combination of integrated Multi-Omic approaches leading to the discovery of two repertoires of polymorphic and/or diversified interacting molecules: the parasite antigens S. mansoni polymorphic mucins (SmPoMucs) and the B. glabrata immune receptors fibrinogen-related proteins (FREPs). We argue that their interactions may be major components for defining the compatible/incompatible status of a specific snail/schistosome combination. •Host and parasite interaction results in a matching-phenotype.•The molecular basis of compatibility polymorphism was reviewed.•Host's pathogen recognition receptors were diversified.•Antigenic polymorphism was observed in parasite populations.•FREPs and SmPoMucs were at the core of the interaction.