Wobble uridine modifications-a reason to live, a reason to die?!

Wobble uridines (U 34 ) are generally modified in all species. U 34 modifications can be essential in metazoans but are not required for viability in fungi. In this review, we provide an overview on the types of modifications and how they affect the physico-chemical properties of wobble uridines. We...

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Bibliographic Details
Published in:RNA biology 2017-09, Vol.14 (9), p.1209-1222
Main Authors: Schaffrath, Raffael, Leidel, Sebastian A.
Format: Article
Language:English
Subjects:
Animalia
Anticodon wobble base
Biological Evolution
Chemical Phenomena
Endoribonucleases - metabolism
eukaryotic cells
fungi
Gene Expression Regulation
Metabolic Networks and Pathways
mitochondria
mRNA translation
phenotype
Phosphorylation
physicochemical properties
Protein Binding
protein homeostasis
Review
ribonucleases
RNA-Binding Proteins - metabolism
RNases
stress responses
Structure-Activity Relationship
transfer RNA
tRNA modification
uridine
Uridine - chemistry
Uridine - genetics
Uridine - metabolism
viability
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