Metabolic syndrome components and estimated glomerular filtration rate based on creatinine and/or cystatin C in young adults: A gender issue?

Abstract Aims This work aims to identify correlations between estimated glomerular filtration rate (eGFR) based on creatinine and/or cystatin C (Cr, CysC) with metabolic syndrome (MS) components in young adults, according to gender. Material and methods This is a cross sectional study, where young a...

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Published in:Diabetes & metabolic syndrome clinical research & reviews 2017-11, Vol.11, p.S351-S357
Main Authors: Medeiros, Thalia, do Rosário, Natalia Fonseca, Gama, Nycole Abreu, Mérida, Lyris Anunciata Demétrio, Storch, Amanda Sampaio, Ferraz, Leda, de Fátima Lopes, Patricia, da Silva, Andrea Alice, Almeida, Jorge Reis
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biomarkers - blood
Brazil - epidemiology
Chronic kidney disease
Creatinine - blood
Cross-Sectional Studies
Cystatin C - blood
Endocrinology & Metabolism
Female
Follow-Up Studies
Glomerular Filtration Rate
Humans
Incidence
Kidney Function Tests
Male
Metabolic syndrome
Metabolic Syndrome - physiopathology
Prognosis
Renal Insufficiency, Chronic - blood
Renal Insufficiency, Chronic - diagnosis
Renal Insufficiency, Chronic - epidemiology
Sex Factors
Young Adult
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Summary:Abstract Aims This work aims to identify correlations between estimated glomerular filtration rate (eGFR) based on creatinine and/or cystatin C (Cr, CysC) with metabolic syndrome (MS) components in young adults, according to gender. Material and methods This is a cross sectional study, where young adults aged between 18 and 30 were matched by gender, age and body mass index. All subjects underwent clinical evaluation and blood sampling for laboratory measurements. MS was determined according to the JIS criteria. The eGFR was estimated using CKD-EPI equations (eGFRCr ; eGFRCysC ; eGFRCr-CysC ). Results We evaluated 78 subjects with a mean age of 24.5 years. 10.2% had MS, with higher incidence among males (15.4% ♂ vs. 5.1% ♀). Elevated waist circumference was the MS component most observed. Significant correlations (Pearson; p < 0.05) between eGFR and metabolic markers were observed only in males. In addition, we observed a significant association between the increase of MS components and the decay of eGFRCr and eGFRCr-CysC (zero vs. two or more components, ANOVA, p < 0.05) only among males. Conclusion eGFR decay associated with components of MS and insulin resistance in young male adults could represent a worrying specific risk and indicate that further studies are needed to better understand these findings.
ISSN:1871-4021
1878-0334
DOI:10.1016/j.dsx.2017.03.015