A new hope for obesity management: Boron inhibits adipogenesis in progenitor cells through the Wnt/β-catenin pathway

Abstract Obesity is a worldwide medical problem resulting in serious morbidity and mortality involving differentiation of pre-adipocytes into mature adipocytes (adipogenesis). Boron treatment has been reported to be associated with weight reduction in experimental animals; however, its effects on pr...

Full description

Saved in:
Bibliographic Details
Published in:Metabolism, clinical and experimental clinical and experimental, 2017-04, Vol.69, p.130-142
Main Authors: Doğan, Ayşegül, Demirci, Selami, Apdik, Hüseyin, Bayrak, Ömer Faruk, Güllüoğlu, Şükrü, Tüysüz, Emrecan, Gusev, Oleg, Rizvanov, Albert A, Nikerel, Emrah, Şahin, Fikrettin
Format: Article
Language:English
Subjects:
3T3-L1 Cells
Adipocytes - drug effects
Adipogenesis
Adipogenesis - drug effects
Adipogenesis - genetics
Adiponectin - biosynthesis
Adiponectin - genetics
Animals
Anti-Obesity Agents - therapeutic use
Borates - pharmacology
Boric Acids - pharmacology
Boron
Boron Compounds - pharmacology
Cell Differentiation - drug effects
Cell Proliferation - drug effects
Cytokines - biosynthesis
Cytokines - genetics
Endocrinology & Metabolism
Gene Expression Regulation - drug effects
Genes, cdc - drug effects
Leptin - biosynthesis
Leptin - genetics
Lipogenesis
Mice
Mitosis - drug effects
Obesity - drug therapy
PPARγ
Stem Cells - drug effects
Wnt Signaling Pathway - drug effects
β-catenin
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Obesity is a worldwide medical problem resulting in serious morbidity and mortality involving differentiation of pre-adipocytes into mature adipocytes (adipogenesis). Boron treatment has been reported to be associated with weight reduction in experimental animals; however, its effects on pre-adipocyte differentiation and anti-adipogenic molecular mechanisms are unknown. In this study, we demonstrate the inhibitory activities of boric acid (BA) and sodium pentaborate pentahydrate (NaB) on adipogenesis using common cellular models. Boron treatment repressed the expression of adipogenesis-related genes and proteins, including CCAAT-enhancer-binding protein α and peroxisome proliferator-activated receptor γ, by regulating critical growth factors and the β-catenin, AKT, and extracellular signal-regulated kinase signaling pathways. In addition, although boron treatment did not induce apoptosis in pre-adipocytes, it depressed mitotic clonal expansion by regulation of cell cycle genes. Overall, these data offer promising insights into the prevention/treatment of obesity and associated diseases.
ISSN:0026-0495
1532-8600
DOI:10.1016/j.metabol.2017.01.021