4D Printing of Shape Memory‐Based Personalized Endoluminal Medical Devices

The convergence of additive manufacturing and shape‐morphing materials is promising for the advancement of personalized medical devices. The capability to transform 3D objects from one shape to another, right off the print bed, is known as 4D printing. Shape memory thermosets can be tailored to have...

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Bibliographic Details
Published in:Macromolecular rapid communications. 2017-01, Vol.38 (2), p.np-n/a
Main Authors: Zarek, Matt, Mansour, Nicola, Shapira, Shir, Cohn, Daniel
Format: Article
Language:English
Subjects:
4D printing
Alloys
biomedical devices
Biomedical materials
Devices
Equipment and Supplies
Medical devices
Medical equipment
Memory devices
Personalized
personalized medicine
Polyesters - chemical synthesis
Polyesters - chemistry
Precision Medicine
Printing
Shape memory
shape‐memory polymers
Stereolithography
Surgical implants
Temperature
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Summary:The convergence of additive manufacturing and shape‐morphing materials is promising for the advancement of personalized medical devices. The capability to transform 3D objects from one shape to another, right off the print bed, is known as 4D printing. Shape memory thermosets can be tailored to have a range of thermomechanical properties favorable to medical devices, but processing them is a challenge because they are insoluble and do not flow at any temperature. This study presents here a strategy to capitalize on a series of medical imaging modalities to construct a printable shape memory endoluminal device, exemplified by a tracheal stent. A methacrylated polycaprolactone precursor with a molecular weight of 10 000 g mol−1 is printed with a UV‐LED stereolithography printer based on anatomical data. This approach converges with the zeitgeist of personalized medicine and it is anticipated that it will broadly expand the application of shape memory‐exhibiting biomedical devices to myriad clinical indications. The 4D fabrication of a shape memory polymer endoluminal device, based on actual anatomic data and melt stereolithography 3D printing is reported. A bespoke tracheal stent demonstrates the possibilities of 3D printed shape memory materials for minimally invasive biomedical devices. This prototype stent suggests a potential step in overcoming the high failure rates associated with standard tracheal stents.
ISSN:1022-1336
1521-3927
DOI:10.1002/marc.201600628