Easy access to triazolinedione-endcapped peptides for chemical ligation

An efficient and easy route towards triazolinedione (TAD) endcapped peptides is described, in which a TAD-precursor was coupled to N-terminal amines on a solid support. Modified peptides readily reacted with diene end-functionalized poly(ε-caprolactone) of different molecular weights. The ligation p...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2017, Vol.53 (3), p.593-596
Main Authors: Wilke, P, Kunde, T, Chattopadhyay, S, Ten Brummelhuis, N, Du Prez, F E, Börner, H G
Format: Article
Language:English
Subjects:
Amines
Amino acids
Dienes
Functional groups
Molecular Weight
Peptides
Peptides - chemistry
Polyesters - chemistry
Triazoles - chemistry
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Summary:An efficient and easy route towards triazolinedione (TAD) endcapped peptides is described, in which a TAD-precursor was coupled to N-terminal amines on a solid support. Modified peptides readily reacted with diene end-functionalized poly(ε-caprolactone) of different molecular weights. The ligation proved to be orthogonal to a variety of functional groups present in natural amino acids.
ISSN:1359-7345
1364-548X
DOI:10.1039/c6cc08683g