Use of a Traceless Activating and Directing Group for the Construction of Trifluoromethylpyrazoles: One‐Pot Transformation of Nitroolefins and Trifluorodiazoethane

We disclose an efficient one‐pot transformation of trifluorodiazoethane and higher perfluorinated homologues with various nitroolefins. This method takes advantage of the nitro group as a traceless activating and directing group (TADG) that is released in the aromatization step to produce 4‐substitu...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2017-04, Vol.56 (16), p.4569-4574
Main Authors: Chen, Zhen, Zheng, Yan, Ma, Jun‐An
Format: Article
Language:English
Subjects:
diazo compounds
Homology
nitroolefins
Pyrazoles
Regioselectivity
traceless directing groups
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