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The natural history of cystic echinococcosis in untreated and albendazole-treated patients
This study provides statistical confirmation that the WHO ultrasound classification of CE reflects the natural history of CE in untreated and albendazole-treated patients. [Display omitted] The World Health Organization (WHO) treatment protocols for cystic echinococcosis (CE) are based on the standa...
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| Published in: | Acta tropica 2017-07, Vol.171, p.52-57 |
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| container_end_page | 57 |
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| container_title | Acta tropica |
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| creator | Solomon, N. Kachani, M. Zeyhle, E. Macpherson, C.N.L. |
| description | This study provides statistical confirmation that the WHO ultrasound classification of CE reflects the natural history of CE in untreated and albendazole-treated patients.
[Display omitted]
The World Health Organization (WHO) treatment protocols for cystic echinococcosis (CE) are based on the standardized ultrasound (US) classification. This study examined whether the classification reflected the natural history of CE in untreated and albendazole-treated patients. Data were collected during mass US screenings in CE endemic regions among transhumant populations, the Turkana and Berber peoples of Kenya and Morocco. Cysts were classified using the WHO classification. Patient records occurring prior to treatment, and after albendazole administration, were selected. 852 paired before/after observations of 360 cysts from 257 patients were analyzed. A McNemar-Bowker χ2 test for symmetry was significant (p |
| doi_str_mv | 10.1016/j.actatropica.2017.03.018 |
| format | article |
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[Display omitted]
The World Health Organization (WHO) treatment protocols for cystic echinococcosis (CE) are based on the standardized ultrasound (US) classification. This study examined whether the classification reflected the natural history of CE in untreated and albendazole-treated patients. Data were collected during mass US screenings in CE endemic regions among transhumant populations, the Turkana and Berber peoples of Kenya and Morocco. Cysts were classified using the WHO classification. Patient records occurring prior to treatment, and after albendazole administration, were selected. 852 paired before/after observations of 360 cysts from 257 patients were analyzed. A McNemar-Bowker χ2 test for symmetry was significant (p<0.0001). 744 observations (87.3%) maintained the same class, and 101 (11.9%) progressed, consistent with the classification. Regression to CE3B occurred in seven of 116 CE4 cyst observations (6.0%). A McNemar-Bowker χ2 test of 1414 paired before/after observations of 288 cysts from 157 albendazole-treated patients was significant (p<0.0001). 1236 observations (87.4%) maintained the same class, and 149 (10.5%) progressed, consistent with the classification. Regression to CE3B occurred in 29 of 206 CE4 observations (14.1%). Significant asymmetry confirms the WHO classification’s applicability to the natural history of CE and albendazole-induced changes. Regressions may reflect the stability of CE3B cysts.</description><identifier>ISSN: 0001-706X</identifier><identifier>EISSN: 1873-6254</identifier><identifier>DOI: 10.1016/j.actatropica.2017.03.018</identifier><identifier>PMID: 28336270</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Albendazole ; Albendazole - therapeutic use ; Anthelmintics - therapeutic use ; Classification ; Cystic echinococcosis ; Echinococcosis - classification ; Echinococcosis - diagnostic imaging ; Echinococcosis - drug therapy ; Echinococcosis - epidemiology ; Female ; Humans ; Kenya - epidemiology ; Male ; Mass Screening ; Medical Records ; Middle Aged ; Morocco - epidemiology ; Natural history ; Parasitology ; Ultrasonography ; Ultrasound</subject><ispartof>Acta tropica, 2017-07, Vol.171, p.52-57</ispartof><rights>2017</rights><rights>Copyright © 2017. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c321t-1f2bec98f89a37479278dba19f53885c653456b046e4e9a89b34688ce01443463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28336270$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Solomon, N.</creatorcontrib><creatorcontrib>Kachani, M.</creatorcontrib><creatorcontrib>Zeyhle, E.</creatorcontrib><creatorcontrib>Macpherson, C.N.L.</creatorcontrib><title>The natural history of cystic echinococcosis in untreated and albendazole-treated patients</title><title>Acta tropica</title><addtitle>Acta Trop</addtitle><description>This study provides statistical confirmation that the WHO ultrasound classification of CE reflects the natural history of CE in untreated and albendazole-treated patients.
[Display omitted]
The World Health Organization (WHO) treatment protocols for cystic echinococcosis (CE) are based on the standardized ultrasound (US) classification. This study examined whether the classification reflected the natural history of CE in untreated and albendazole-treated patients. Data were collected during mass US screenings in CE endemic regions among transhumant populations, the Turkana and Berber peoples of Kenya and Morocco. Cysts were classified using the WHO classification. Patient records occurring prior to treatment, and after albendazole administration, were selected. 852 paired before/after observations of 360 cysts from 257 patients were analyzed. A McNemar-Bowker χ2 test for symmetry was significant (p<0.0001). 744 observations (87.3%) maintained the same class, and 101 (11.9%) progressed, consistent with the classification. Regression to CE3B occurred in seven of 116 CE4 cyst observations (6.0%). A McNemar-Bowker χ2 test of 1414 paired before/after observations of 288 cysts from 157 albendazole-treated patients was significant (p<0.0001). 1236 observations (87.4%) maintained the same class, and 149 (10.5%) progressed, consistent with the classification. Regression to CE3B occurred in 29 of 206 CE4 observations (14.1%). Significant asymmetry confirms the WHO classification’s applicability to the natural history of CE and albendazole-induced changes. Regressions may reflect the stability of CE3B cysts.</description><subject>Adult</subject><subject>Albendazole</subject><subject>Albendazole - therapeutic use</subject><subject>Anthelmintics - therapeutic use</subject><subject>Classification</subject><subject>Cystic echinococcosis</subject><subject>Echinococcosis - classification</subject><subject>Echinococcosis - diagnostic imaging</subject><subject>Echinococcosis - drug therapy</subject><subject>Echinococcosis - epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>Kenya - epidemiology</subject><subject>Male</subject><subject>Mass Screening</subject><subject>Medical Records</subject><subject>Middle Aged</subject><subject>Morocco - epidemiology</subject><subject>Natural history</subject><subject>Parasitology</subject><subject>Ultrasonography</subject><subject>Ultrasound</subject><issn>0001-706X</issn><issn>1873-6254</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNqNkEtLxDAQx4Mouj6-gtSbl9Y82jQ9yuILBC8K4iWk0ymbpdusSSqsn94sq-LRwzAP_vMf5kfIBaMFo0xeLQsD0UTv1hZMwSmrCyoKytQemTFVi1zyqtwnM0opy2sqX4_IcQjL1PG64ofkiCshJK_pjLw9LzAbTZy8GbKFDdH5Teb6DDYhWsgQFnZ04ABcsCGzYzaN0aOJ2GVmTDG0OHbm0w2Y_8zXJlocYzglB70ZAp595xPycnvzPL_PH5_uHubXjzkIzmLOet4iNKpXjRF1WTe8Vl1rWNNXQqkKZCXKSra0lFhiY1TTilIqBUhZWaZSnJDLne_au_cJQ9QrGwCHwYzopqCZUozLKvkmabOTgncheOz12tuV8RvNqN6i1Uv9B63eotVU6IQ27Z5_n5naFXa_mz8sk2C-E2B69sOi1wESCMDOeoSoO2f_ceYLdtqRDA</recordid><startdate>201707</startdate><enddate>201707</enddate><creator>Solomon, N.</creator><creator>Kachani, M.</creator><creator>Zeyhle, E.</creator><creator>Macpherson, C.N.L.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201707</creationdate><title>The natural history of cystic echinococcosis in untreated and albendazole-treated patients</title><author>Solomon, N. ; Kachani, M. ; Zeyhle, E. ; Macpherson, C.N.L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c321t-1f2bec98f89a37479278dba19f53885c653456b046e4e9a89b34688ce01443463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Albendazole</topic><topic>Albendazole - therapeutic use</topic><topic>Anthelmintics - therapeutic use</topic><topic>Classification</topic><topic>Cystic echinococcosis</topic><topic>Echinococcosis - classification</topic><topic>Echinococcosis - diagnostic imaging</topic><topic>Echinococcosis - drug therapy</topic><topic>Echinococcosis - epidemiology</topic><topic>Female</topic><topic>Humans</topic><topic>Kenya - epidemiology</topic><topic>Male</topic><topic>Mass Screening</topic><topic>Medical Records</topic><topic>Middle Aged</topic><topic>Morocco - epidemiology</topic><topic>Natural history</topic><topic>Parasitology</topic><topic>Ultrasonography</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Solomon, N.</creatorcontrib><creatorcontrib>Kachani, M.</creatorcontrib><creatorcontrib>Zeyhle, E.</creatorcontrib><creatorcontrib>Macpherson, C.N.L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta tropica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Solomon, N.</au><au>Kachani, M.</au><au>Zeyhle, E.</au><au>Macpherson, C.N.L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The natural history of cystic echinococcosis in untreated and albendazole-treated patients</atitle><jtitle>Acta tropica</jtitle><addtitle>Acta Trop</addtitle><date>2017-07</date><risdate>2017</risdate><volume>171</volume><spage>52</spage><epage>57</epage><pages>52-57</pages><issn>0001-706X</issn><eissn>1873-6254</eissn><abstract>This study provides statistical confirmation that the WHO ultrasound classification of CE reflects the natural history of CE in untreated and albendazole-treated patients.
[Display omitted]
The World Health Organization (WHO) treatment protocols for cystic echinococcosis (CE) are based on the standardized ultrasound (US) classification. This study examined whether the classification reflected the natural history of CE in untreated and albendazole-treated patients. Data were collected during mass US screenings in CE endemic regions among transhumant populations, the Turkana and Berber peoples of Kenya and Morocco. Cysts were classified using the WHO classification. Patient records occurring prior to treatment, and after albendazole administration, were selected. 852 paired before/after observations of 360 cysts from 257 patients were analyzed. A McNemar-Bowker χ2 test for symmetry was significant (p<0.0001). 744 observations (87.3%) maintained the same class, and 101 (11.9%) progressed, consistent with the classification. Regression to CE3B occurred in seven of 116 CE4 cyst observations (6.0%). A McNemar-Bowker χ2 test of 1414 paired before/after observations of 288 cysts from 157 albendazole-treated patients was significant (p<0.0001). 1236 observations (87.4%) maintained the same class, and 149 (10.5%) progressed, consistent with the classification. Regression to CE3B occurred in 29 of 206 CE4 observations (14.1%). Significant asymmetry confirms the WHO classification’s applicability to the natural history of CE and albendazole-induced changes. Regressions may reflect the stability of CE3B cysts.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>28336270</pmid><doi>10.1016/j.actatropica.2017.03.018</doi><tpages>6</tpages></addata></record> |
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| ispartof | Acta tropica, 2017-07, Vol.171, p.52-57 |
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| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Adult Albendazole Albendazole - therapeutic use Anthelmintics - therapeutic use Classification Cystic echinococcosis Echinococcosis - classification Echinococcosis - diagnostic imaging Echinococcosis - drug therapy Echinococcosis - epidemiology Female Humans Kenya - epidemiology Male Mass Screening Medical Records Middle Aged Morocco - epidemiology Natural history Parasitology Ultrasonography Ultrasound |
| title | The natural history of cystic echinococcosis in untreated and albendazole-treated patients |
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