Co-infection of blood borne viruses in blood donors: A cross-sectional study from North India

Abstract Background There are several studies on prevalence of individual infectious disease markers (mono-infection) in donors but none on prevalence of coinfection. Co-infection is significant as it leads to accelerated disease progression. We, therefore, evaluated the prevalence of co-infection a...

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Published in:Transfusion and apheresis science 2017-06, Vol.56 (3), p.367-370
Main Authors: Dara, Ravi C, Tiwari, Aseem K, Arora, Dinesh, Aggarwal, Geet, Rawat, Ganesh Singh, Sharma, Jyoti, Acharya, Devi Prasad, Bhardwaj, Gunjan
Format: Article
Language:English
Subjects:
Adolescent
Adult
Blood Donors
Co-infection
Coinfection
Cross-Sectional Studies
Female
Health technology assessment
Hematology, Oncology and Palliative Medicine
Hepatitis B
Hepatitis B - epidemiology
Hepatitis C
Hepatitis C - epidemiology
HIV Infections - epidemiology
Human immunodeficiency virus
Humans
India
Male
Middle Aged
Retrospective Studies
Young Adult
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Summary:Abstract Background There are several studies on prevalence of individual infectious disease markers (mono-infection) in donors but none on prevalence of coinfection. Co-infection is significant as it leads to accelerated disease progression. We, therefore, evaluated the prevalence of co-infection among blood donors. Materials and methods The cross-sectional analysis was conducted in blood donors. All donors were tested for anti-HIV I and II, HBsAg, anti-HBC IgM, anti-HCV, Malaria and syphilis by chemiluminescence and ID-NAT assay. All reactive donor samples were confirmed by using confirmatory assays. Donors were grouped as mono-infected and co-infected. The student t -test was used for comparison. Results During the study period, a total of 106,238 blood donors were tested. Mean age of donors was 34.2 years and 94.2% of blood donors were males. 1776 (1.67%) donor samples were confirmed serologically reactive. 1714 (1.61%) samples were reactive for single marker (mono-infected) while 62 (0.05%) donors’ samples exhibited co-infection. 18 donors were positive for HBV+HCV followed by HIV +syphilis (14). Conclusion We report for the first time the prevalence of different co-infection patterns in blood donors. Co-infection influence the disease progression; it would be important to investigate the co-infection prevalence in larger sample size.
ISSN:1473-0502
1878-1683
DOI:10.1016/j.transci.2017.02.004