Developing a paediatric drug formulary for the Netherlands

As many drugs in paediatrics are used off-label, prescribers face a lack of evidence-based dosing guidelines. A Dutch framework was developed to provide dosing guidelines based on best available evidence from registration data, investigator-initiated research, professional guidelines, clinical exper...

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Bibliographic Details
Published in:Archives of disease in childhood 2017-04, Vol.102 (4), p.357-361
Main Authors: van der Zanden, Tjitske M, de Wildt, Saskia N, Liem, Yves, Offringa, Martin, de Hoog, Matthijs
Format: Article
Language:English
Subjects:
Child
Children
Comparative Analysis
Consensus
Cultural Differences
Drug Administration Schedule
Drug Approval
Drug therapy
Drug Use
Evidence Based Practice
Evidence-Based Medicine
Formularies as Topic
Full Time Equivalency
Health aspects
Humans
Knowledge Bases
Marketing
Narcotics
Netherlands
Off-Label Use
Safety and security measures
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Summary:As many drugs in paediatrics are used off-label, prescribers face a lack of evidence-based dosing guidelines. A Dutch framework was developed to provide dosing guidelines based on best available evidence from registration data, investigator-initiated research, professional guidelines, clinical experience and consensus. This has clarified the scientific grounds of drug use for children and encouraged uniformity in prescribing habits in the Netherlands. The developed framework and the current content of the Dutch Paediatric Formulary could be used as basis for similar initiatives worldwide, preferably in a concerted effort to ultimately provide children with effective and safe drug therapy.
ISSN:0003-9888
1468-2044
DOI:10.1136/archdischild-2016-311674