Question 1: Is a low-bacterial diet helpful in preventing infection in immunosuppressed children?

Quality of life assessed by survey but no further details given van Dalen et al 3 Systematic review-studies included from the USA and the Netherlands 192 adults and children with various malignancies (age and sex not stated) Systematic review of RCTs 1a Not stated Infection rate Time to first febril...

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Bibliographic Details
Published in:Archives of disease in childhood 2017-04, Vol.102 (4), p.380-382
Main Authors: Friend, Amanda J, Maltby, Sarah
Format: Article
Language:English
Subjects:
Brain cancer
Brain tumors
Children & youth
Diet
E coli
Evidence
Food Standards
Heterogeneity
Infections
Males
Meta Analysis
Microbiology
Neutropenia
Nutrition research
Patients
Pediatrics
Pneumonia
Quality of life
Sarcoma
Studies
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Summary:Quality of life assessed by survey but no further details given van Dalen et al 3 Systematic review-studies included from the USA and the Netherlands 192 adults and children with various malignancies (age and sex not stated) Systematic review of RCTs 1a Not stated Infection rate Time to first febrile episode Diet acceptability No evidence of reduced infection rate in patients following low-bacterial diet guidelines No significant difference between groups No significant difference between groups Due to heterogeneity of studies, meta-analysis was not able to be carried out Moody et al 4 USA 19 children aged 1-18 years, 8 of whom were male. Diagnoses were ALL, sarcoma or brain tumour Small RCT 2b Duration of study (up to 8 months) Episodes of febrile neutropenia Quality of life (determined by Peds QL Pediatric Quality of Life Inventory Core Module and Cancer Module) Dietary acceptability No significant difference between groups No significant difference between groups No significant difference between groups Included in the systematic review by van Dalen et al Tabori et al 5 Canada 34 children aged 6-17 years, 16 of whom were male, who were being treated for ALL, brain tumour or other solid tumour Small cohort study 3b N/A-no intervention (study looked at 2-week camp period) Episodes of fever Positive microbiology Four children admitted to hospital with fever One child with positive virology for herpes (gingivostomatitis) and positive blood cultures for Escherichia coli and Staphylococcus aureus likely from central line Cohort study in group not following specific diet, no 'control' group, however, overall rate of infection appears low RCT, randomised controlled trial.
ISSN:0003-9888
1468-2044
DOI:10.1136/archdischild-2016-312125