Release of lead from bone in pregnancy and lactation

Concentrations and isotope ratios of lead in blood, urine, 24-h duplicate diets, and hand wipes were measured for 12 women from the second trimester of pregnancy until at least 8 months after delivery. Six bottle fed and six breast fed their infants. One bottle feeder fell pregnant for a second time...

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Bibliographic Details
Published in:Environmental research 2003-06, Vol.92 (2), p.139-151
Main Authors: Manton, W.I., Angle, C.R., Stanek, K.L., Kuntzelman, D., Reese, Y.R., Kuehnemann, T.J.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Blood lead
Bone and Bones - metabolism
Bone lead
Bone Remodeling - physiology
Bottle Feeding
Breast Feeding
Chemical and industrial products toxicology. Toxic occupational diseases
Female
Humans
Lactation
Lead - blood
Lead - metabolism
Lead isotope ratios
Lead Radioisotopes
Longitudinal Studies
Medical sciences
Metals and various inorganic compounds
Postpartum Period - blood
Postpartum Period - metabolism
Pregnancy
Pregnancy - blood
Pregnancy - metabolism
Toxicology
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Summary:Concentrations and isotope ratios of lead in blood, urine, 24-h duplicate diets, and hand wipes were measured for 12 women from the second trimester of pregnancy until at least 8 months after delivery. Six bottle fed and six breast fed their infants. One bottle feeder fell pregnant for a second time, as did a breast feeder, and each was followed semicontinuously for totals of 44 and 54 months, respectively. Bone resorption rather than dietary absorption controls changes in blood lead, but in pregnancy the resorption of trabecular and cortical bone are decoupled. In early pregnancy, only trabecular bone (presumably of low lead content) is resorbed, causing blood leads to fall more than expected from hemodilution alone. In late pregnancy, the sites of resorption move to cortical bone of higher lead content and blood leads rise. In bottle feeders, the cortical bone contribution ceases immediately after delivery, but any tendency for blood leads to fall may be compensated by the effect of hemoconcentration produced by the postpartum loss of plasma volume. In lactation, the whole skeleton undergoes resorption and the blood leads of nursing mothers continue to rise, reaching a maximum 6–8 months after delivery. Blood leads fall from pregnancy to pregnancy, implying that the greatest risk of lead toxicity lies with first pregnancies.
ISSN:0013-9351
1096-0953
DOI:10.1016/S0013-9351(03)00020-3