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Correction of Abnormalities Provoked by Long-Term Alcoholization with Hypoxic-Hyperoxic Training
Free radical oxidation in the liver and skeletal muscles as well as stress behavior were examined in rats subjected to a gradual long-term alcoholization with elevated ethanol content from 10 to 40% followed by correction of alcohol-induced disturbances with hypoxic-hyperoxic training. The elevated...
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| Published in: | Bulletin of experimental biology and medicine 2017-03, Vol.162 (5), p.624-628 |
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| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c470t-471dfaf78724d88575745a509f8e096d623d6f75867f725bc93fd618193afdbe3 |
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| cites | cdi_FETCH-LOGICAL-c470t-471dfaf78724d88575745a509f8e096d623d6f75867f725bc93fd618193afdbe3 |
| container_end_page | 628 |
| container_issue | 5 |
| container_start_page | 624 |
| container_title | Bulletin of experimental biology and medicine |
| container_volume | 162 |
| creator | Sazontova, T. G. Stryapko, N. V. Arkhipenko, Yu. V. |
| description | Free radical oxidation in the liver and skeletal muscles as well as stress behavior were examined in rats subjected to a gradual long-term alcoholization with elevated ethanol content from 10 to 40% followed by correction of alcohol-induced disturbances with hypoxic-hyperoxic training. The elevated plus-maze test revealed increased anxiety and appearance of risky behavior in alcoholized rats in the absence of changes in motor and orientation activity. In the liver and skeletal muscles of alcoholized rats, free radical oxidation processes were decompensated despite activation of antioxidant enzymes. Adaptation to intermittent hypoxia-hyperoxia during last two weeks of alcoholization exerted a protective effect against ethanol-induced oxidative stress: reduced anxious and risk behavior, normalized tissue tolerance of free radical oxidation processes, and restored the level of protective proteins. |
| doi_str_mv | 10.1007/s10517-017-3672-7 |
| format | article |
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| ispartof | Bulletin of experimental biology and medicine, 2017-03, Vol.162 (5), p.624-628 |
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| subjects | Adaptation, Physiological Alcoholism - metabolism Animals Antioxidants (Nutrients) Anxiety Anxiety - chemically induced Anxiety - metabolism Biomedical and Life Sciences Biomedicine Catalase - metabolism Cell Biology Cell Hypoxia Enzymes Ethanol Ethanol - adverse effects Free radicals Health aspects Hyperoxia Hyperoxia - metabolism Hypoxia Internal Medicine Laboratory Medicine Liver Liver - drug effects Liver - enzymology Male Motor task performance Oxidative Stress Pathology Protective Factors Rats, Wistar Reactive Oxygen Species Risk-Taking Rodents Skeletal muscle Superoxide Dismutase - metabolism |
| title | Correction of Abnormalities Provoked by Long-Term Alcoholization with Hypoxic-Hyperoxic Training |
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