Evaluation of electrospun PLLA/PEGDMA polymer coatings for vascular stent material

The field of percutaneous coronary intervention has seen a plethora of advances over the past few decades, which have allowed for its development into safe and effective treatments for patients suffering from cardiovascular diseases. However, stent thrombosis and in-stent restenosis remain clinicall...

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Bibliographic Details
Published in:Journal of biomaterials science. Polymer ed. 2016-07, Vol.27 (11), p.1086-1099
Main Authors: Boodagh, Parnaz, Guo, Dong-Jie, Nagiah, Naveen, Tan, Wei
Format: Article
Language:English
Subjects:
Attachment
biomaterials
Coatings
electrospin
Electrospinning
Intermetallics
nanofibrous materials
Nickel titanides
Platelets
polymers
Shape memory alloys
Stent coating
Surgical implants
thrombosis
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Summary:The field of percutaneous coronary intervention has seen a plethora of advances over the past few decades, which have allowed for its development into safe and effective treatments for patients suffering from cardiovascular diseases. However, stent thrombosis and in-stent restenosis remain clinically significant problems. Herein, we describe the synthesis and characterization of fibrous polymer coatings on stent material nitinol, in the hopes of developing a more suitable stent surface to enhance re-endothelialization. Electrospinning technique was used to fabricate polyethylene glycol dimethacrylate/poly l-lactide acid (PEGDMA/PLLA) blend fiber substrate with tunable elasticity and hydrophilicity for use as coatings. Attachment of platelets and arterial smooth muscle cells (SMC) onto the coatings as well as the secretory effect of mesenchymal stem cells cultured on the coatings on the proliferation and migration of arterial endothelial cells and SMCs were assessed. It was demonstrated that electrospun PEGDMA/PLLA coating with 1:1 ratio of the components on the nitinol stent-reduced platelet and SMC attachment and increased stem cell secretory factors that enhance endothelial proliferation. We therefore postulate that the fibrous coating surface would possess enhanced biological compatibility of nitinol stents and hold the potential in preventing stent failure through restenosis and thrombosis.
ISSN:0920-5063
1568-5624
DOI:10.1080/09205063.2016.1176715