Loading…

Beyond the midbrain atrophy: wide spectrum of structural MRI finding in cases of pathologically proven progressive supranuclear palsy

Purpose Recently, it has been recognized that pathologically proven progressive supranuclear palsy (PSP) cases are classified into various clinical subtypes with non-uniform symptoms and imaging findings. This article reviews essential imaging findings, general information, and advanced magnetic res...

Full description

Saved in:
Bibliographic Details
Published in:Neuroradiology 2017-05, Vol.59 (5), p.431-443
Main Authors: Sakurai, Keita, Tokumaru, Aya M, Shimoji, Keigo, Murayama, Shigeo, Kanemaru, Kazutomi, Morimoto, Satoru, Aiba, Ikuko, Nakagawa, Motoo, Ozawa, Yoshiyuki, Shimohira, Masashi, Matsukawa, Noriyuki, Hashizume, Yoshio, Shibamoto, Yuta
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose Recently, it has been recognized that pathologically proven progressive supranuclear palsy (PSP) cases are classified into various clinical subtypes with non-uniform symptoms and imaging findings. This article reviews essential imaging findings, general information, and advanced magnetic resonance imaging (MRI) techniques for PSP and presents these MRI findings of pathologically proven typical and atypical PSP cases for educational purposes. Methods With the review of literatures, notably including atypical pathologically proven PSP cases, MRI and clinical information of 15 pathologically proven typical and atypical PSP cases were retrospectively evaluated. Results In addition to typical symptoms, PSP patients can exhibit atypical symptoms including levodopa-responsive parkinsonism, pure akinesia, non-fluent aphasia, corticobasal syndrome, and predominant cerebellar ataxia. As well as clinical symptoms, the degree of midbrain atrophy, a well-known imaging hallmark, is not consistent in atypical PSP cases. This fact has important implications for the limitation of midbrain atrophy as a diagnostic imaging biomarker of PSP pathology. Additional evaluation of other imaging findings including various regional atrophies of the globus pallidus, frontal lobe, cerebral peduncle, and superior cerebellar peduncle is essential for the diagnosis of atypical PSP cases. Conclusion It is necessary for radiologists to recognize the wide clinical and radiological spectra of typical and atypical PSP cases.
ISSN:0028-3940
1432-1920
DOI:10.1007/s00234-017-1812-4