Chikusetsu (CHI) triggers mitochondria-regulated apoptosis in human prostate cancer via reactive oxygen species (ROS) production

Abstract The prostate cancer prognosis is still not fully understood. Chikusetsu saponin Iva (CHI), isolated from Aralia taibaiensis , shows anti-cancer and anti-inflammatory properties. Here, in our study, we attempted to explore the efficiency and the possible molecular mechanism by which CHI may...

Full description

Saved in:
Bibliographic Details
Published in:Biomedicine & pharmacotherapy 2017-06, Vol.90, p.446-454
Main Authors: Zhu, Wen-bin, Tian, Fu-jun, Liu, Li-qian
Format: Article
Language:English
Subjects:
Apoptosis
Apoptosis - drug effects
Apoptosis Inducing Factor - metabolism
Caspases - metabolism
Cell Line, Tumor
Cell Proliferation - drug effects
Chikusetsu saponin Iva
Endodeoxyribonucleases - metabolism
Humans
Internal Medicine
Male
Medical Education
Mitochondria - drug effects
Mitochondria - metabolism
Oleanolic Acid - analogs & derivatives
Oleanolic Acid - pharmacology
Prostate cancer
Prostatic Neoplasms - drug therapy
Prostatic Neoplasms - metabolism
Reactive Oxygen Species - metabolism
ROS
Saponins - pharmacology
Signal Transduction - drug effects
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract The prostate cancer prognosis is still not fully understood. Chikusetsu saponin Iva (CHI), isolated from Aralia taibaiensis , shows anti-cancer and anti-inflammatory properties. Here, in our study, we attempted to explore the efficiency and the possible molecular mechanism by which CHI may suppress prostate cancer. CHI was found to inhibit prostate cancer cell proliferation and induce cell death without cytotoxicity in prostate normal cells. CHI resulted in intracellular reactive oxygen species (ROS) production, and induced apoptosis regulated by mitochondria in vitro studies. CHI-caused apoptosis was shown in both caspase-dependent and −independent manner, which released cyto-c, enhancing caspases expression and promoting apoptosis-inducing factors (AIF) as well as endonuclease G (Endo G) nuclear transfer, respectively. Moreover, in vivo study showed that prostate tumor was inhibited by CHI administration through apoptosis induction. Thus, the results illustrated that CHI might be an effective therapeutic strategy for prostate cancer treatment in future.
ISSN:0753-3322
1950-6007
DOI:10.1016/j.biopha.2017.03.050